Reduction of lamin B receptor levels by miR-340-5p disrupts chromatin, promotes cell senescence and enhances senolysis

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Standard

Reduction of lamin B receptor levels by miR-340-5p disrupts chromatin, promotes cell senescence and enhances senolysis. / Herman, Allison B.; Anerillas, Carlos; Harris, Sophia C.; Munk, Rachel; Martindale, Jennifer L.; Yang, Xiaoling; Mazan-Mamczarz, Krystyna; Zhang, Yongqing; Heckenbach, Indra J.; Scheibye-Knudsen, Morten; De, Supriyo; Sen, Payel; Abdelmohsen, Kotb; Gorospe, Myriam.

I: Nucleic Acids Research, Bind 49, Nr. 13, 2021, s. 7389-7405.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Herman, AB, Anerillas, C, Harris, SC, Munk, R, Martindale, JL, Yang, X, Mazan-Mamczarz, K, Zhang, Y, Heckenbach, IJ, Scheibye-Knudsen, M, De, S, Sen, P, Abdelmohsen, K & Gorospe, M 2021, 'Reduction of lamin B receptor levels by miR-340-5p disrupts chromatin, promotes cell senescence and enhances senolysis', Nucleic Acids Research, bind 49, nr. 13, s. 7389-7405. https://doi.org/10.1093/nar/gkab538

APA

Herman, A. B., Anerillas, C., Harris, S. C., Munk, R., Martindale, J. L., Yang, X., Mazan-Mamczarz, K., Zhang, Y., Heckenbach, I. J., Scheibye-Knudsen, M., De, S., Sen, P., Abdelmohsen, K., & Gorospe, M. (2021). Reduction of lamin B receptor levels by miR-340-5p disrupts chromatin, promotes cell senescence and enhances senolysis. Nucleic Acids Research, 49(13), 7389-7405. https://doi.org/10.1093/nar/gkab538

Vancouver

Herman AB, Anerillas C, Harris SC, Munk R, Martindale JL, Yang X o.a. Reduction of lamin B receptor levels by miR-340-5p disrupts chromatin, promotes cell senescence and enhances senolysis. Nucleic Acids Research. 2021;49(13):7389-7405. https://doi.org/10.1093/nar/gkab538

Author

Herman, Allison B. ; Anerillas, Carlos ; Harris, Sophia C. ; Munk, Rachel ; Martindale, Jennifer L. ; Yang, Xiaoling ; Mazan-Mamczarz, Krystyna ; Zhang, Yongqing ; Heckenbach, Indra J. ; Scheibye-Knudsen, Morten ; De, Supriyo ; Sen, Payel ; Abdelmohsen, Kotb ; Gorospe, Myriam. / Reduction of lamin B receptor levels by miR-340-5p disrupts chromatin, promotes cell senescence and enhances senolysis. I: Nucleic Acids Research. 2021 ; Bind 49, Nr. 13. s. 7389-7405.

Bibtex

@article{ffe77e0f39cc41a0a515c4da6ec9ba62,
title = "Reduction of lamin B receptor levels by miR-340-5p disrupts chromatin, promotes cell senescence and enhances senolysis",
abstract = "A major stress response influenced by microRNAs (miRNAs) is senescence, a state of indefinite growth arrest triggered by sublethal cell damage. Here, through bioinformatic analysis and experimental validation, we identified miR-340-5p as a novel miRNA that foments cellular senescence. miR-340-5p was highly abundant in diverse senescence models, and miR-340-5p overexpression in proliferating cells rendered them senescent. Among the target mRNAs, miR-340-5p prominently reduced the levels of LBR mRNA, encoding lamin B receptor (LBR). Loss of LBR by ectopic overexpression of miR-340-5p derepressed heterochromatin in lamina-associated domains, promoting the expression of DNA repetitive elements characteristic of senescence. Importantly, overexpressing miR-340-5p enhanced cellular sensitivity to senolytic compounds, while antagonization of miR-340-5p reduced senescent cell markers and engendered resistance to senolytic-induced cell death. We propose that miR-340-5p can be exploited for removing senescent cells to restore tissue homeostasis and mitigate damage by senescent cells in pathologies of human aging. ",
author = "Herman, {Allison B.} and Carlos Anerillas and Harris, {Sophia C.} and Rachel Munk and Martindale, {Jennifer L.} and Xiaoling Yang and Krystyna Mazan-Mamczarz and Yongqing Zhang and Heckenbach, {Indra J.} and Morten Scheibye-Knudsen and Supriyo De and Payel Sen and Kotb Abdelmohsen and Myriam Gorospe",
note = "Publisher Copyright: {\textcopyright} 2021 Published by Oxford University Press on behalf of Nucleic Acids Research 2021.",
year = "2021",
doi = "10.1093/nar/gkab538",
language = "English",
volume = "49",
pages = "7389--7405",
journal = "Nucleic Acids Research",
issn = "0305-1048",
publisher = "Oxford University Press",
number = "13",

}

RIS

TY - JOUR

T1 - Reduction of lamin B receptor levels by miR-340-5p disrupts chromatin, promotes cell senescence and enhances senolysis

AU - Herman, Allison B.

AU - Anerillas, Carlos

AU - Harris, Sophia C.

AU - Munk, Rachel

AU - Martindale, Jennifer L.

AU - Yang, Xiaoling

AU - Mazan-Mamczarz, Krystyna

AU - Zhang, Yongqing

AU - Heckenbach, Indra J.

AU - Scheibye-Knudsen, Morten

AU - De, Supriyo

AU - Sen, Payel

AU - Abdelmohsen, Kotb

AU - Gorospe, Myriam

N1 - Publisher Copyright: © 2021 Published by Oxford University Press on behalf of Nucleic Acids Research 2021.

PY - 2021

Y1 - 2021

N2 - A major stress response influenced by microRNAs (miRNAs) is senescence, a state of indefinite growth arrest triggered by sublethal cell damage. Here, through bioinformatic analysis and experimental validation, we identified miR-340-5p as a novel miRNA that foments cellular senescence. miR-340-5p was highly abundant in diverse senescence models, and miR-340-5p overexpression in proliferating cells rendered them senescent. Among the target mRNAs, miR-340-5p prominently reduced the levels of LBR mRNA, encoding lamin B receptor (LBR). Loss of LBR by ectopic overexpression of miR-340-5p derepressed heterochromatin in lamina-associated domains, promoting the expression of DNA repetitive elements characteristic of senescence. Importantly, overexpressing miR-340-5p enhanced cellular sensitivity to senolytic compounds, while antagonization of miR-340-5p reduced senescent cell markers and engendered resistance to senolytic-induced cell death. We propose that miR-340-5p can be exploited for removing senescent cells to restore tissue homeostasis and mitigate damage by senescent cells in pathologies of human aging.

AB - A major stress response influenced by microRNAs (miRNAs) is senescence, a state of indefinite growth arrest triggered by sublethal cell damage. Here, through bioinformatic analysis and experimental validation, we identified miR-340-5p as a novel miRNA that foments cellular senescence. miR-340-5p was highly abundant in diverse senescence models, and miR-340-5p overexpression in proliferating cells rendered them senescent. Among the target mRNAs, miR-340-5p prominently reduced the levels of LBR mRNA, encoding lamin B receptor (LBR). Loss of LBR by ectopic overexpression of miR-340-5p derepressed heterochromatin in lamina-associated domains, promoting the expression of DNA repetitive elements characteristic of senescence. Importantly, overexpressing miR-340-5p enhanced cellular sensitivity to senolytic compounds, while antagonization of miR-340-5p reduced senescent cell markers and engendered resistance to senolytic-induced cell death. We propose that miR-340-5p can be exploited for removing senescent cells to restore tissue homeostasis and mitigate damage by senescent cells in pathologies of human aging.

U2 - 10.1093/nar/gkab538

DO - 10.1093/nar/gkab538

M3 - Journal article

C2 - 34181735

AN - SCOPUS:85112127285

VL - 49

SP - 7389

EP - 7405

JO - Nucleic Acids Research

JF - Nucleic Acids Research

SN - 0305-1048

IS - 13

ER -

ID: 276271477