Recurrence of bacteremia and infective endocarditis according to bacterial species of index endocarditis episode
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Recurrence of bacteremia and infective endocarditis according to bacterial species of index endocarditis episode. / Østergaard, Lauge; Voldstedlund, Marianne; Bruun, Niels Eske; Bundgaard, Henning; Iversen, Kasper; Pries-Heje, Mia Marie; Hadji-Turdeghal, Katra; Graversen, Peter L.; Moser, Claus; Andersen, Christian Østergaard; Søgaard, Kirstine Kobberøe; Køber, Lars; Fosbøl, Emil Loldrup.
I: Infection, Bind 51, 2023, s. 1739–1747.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Recurrence of bacteremia and infective endocarditis according to bacterial species of index endocarditis episode
AU - Østergaard, Lauge
AU - Voldstedlund, Marianne
AU - Bruun, Niels Eske
AU - Bundgaard, Henning
AU - Iversen, Kasper
AU - Pries-Heje, Mia Marie
AU - Hadji-Turdeghal, Katra
AU - Graversen, Peter L.
AU - Moser, Claus
AU - Andersen, Christian Østergaard
AU - Søgaard, Kirstine Kobberøe
AU - Køber, Lars
AU - Fosbøl, Emil Loldrup
N1 - Publisher Copyright: © 2023, The Author(s).
PY - 2023
Y1 - 2023
N2 - Purpose: In patients surviving infective endocarditis (IE) recurrence of bacteremia or IE is feared. However, knowledge is sparse on the incidence and risk factors for the recurrence of bacteremia or IE. Methods: Using Danish nationwide registries (2010–2020), we identified patients with first-time IE which were categorized by bacterial species (Staphylococcus aureus, Enterococcus spp., Streptococcus spp., coagulase-negative staphylococci [CoNS], ‘Other’ microbiological etiology). Recurrence of bacteremia (including IE episodes) or IE with the same bacterial species was estimated at 12 months and 5 years, considering death as a competing risk. Cox regression models were used to compute adjusted hazard ratios of the recurrence of bacteremia or IE. Results: We identified 4086 patients with IE; 1374 (33.6%) with S. aureus, 813 (19.9%) with Enterococcus spp., 1366 (33.4%) with Streptococcus spp., 284 (7.0%) with CoNS, and 249 (6.1%) with ‘Other’. The overall 12-month incidence of recurrent bacteremia with the same bacterial species was 4.8% and 2.6% with an accompanying IE diagnosis, while this was 7.7% and 4.0%, respectively, with 5 years of follow-up. S. aureus, Enterococcus spp., CoNS, chronic renal failure, and liver disease were associated with an increased rate of recurrent bacteremia or IE with the same bacterial species. Conclusion: Recurrent bacteremia with the same bacterial species within 12 months, occurred in almost 5% and 2.6% for recurrent IE. S. aureus, Enterococcus spp., and CoNS were associated with recurrent infections with the same bacterial species.
AB - Purpose: In patients surviving infective endocarditis (IE) recurrence of bacteremia or IE is feared. However, knowledge is sparse on the incidence and risk factors for the recurrence of bacteremia or IE. Methods: Using Danish nationwide registries (2010–2020), we identified patients with first-time IE which were categorized by bacterial species (Staphylococcus aureus, Enterococcus spp., Streptococcus spp., coagulase-negative staphylococci [CoNS], ‘Other’ microbiological etiology). Recurrence of bacteremia (including IE episodes) or IE with the same bacterial species was estimated at 12 months and 5 years, considering death as a competing risk. Cox regression models were used to compute adjusted hazard ratios of the recurrence of bacteremia or IE. Results: We identified 4086 patients with IE; 1374 (33.6%) with S. aureus, 813 (19.9%) with Enterococcus spp., 1366 (33.4%) with Streptococcus spp., 284 (7.0%) with CoNS, and 249 (6.1%) with ‘Other’. The overall 12-month incidence of recurrent bacteremia with the same bacterial species was 4.8% and 2.6% with an accompanying IE diagnosis, while this was 7.7% and 4.0%, respectively, with 5 years of follow-up. S. aureus, Enterococcus spp., CoNS, chronic renal failure, and liver disease were associated with an increased rate of recurrent bacteremia or IE with the same bacterial species. Conclusion: Recurrent bacteremia with the same bacterial species within 12 months, occurred in almost 5% and 2.6% for recurrent IE. S. aureus, Enterococcus spp., and CoNS were associated with recurrent infections with the same bacterial species.
KW - Bacteremia
KW - Infective endocarditis
KW - Recurrence
KW - Reinfection
KW - Relapse
U2 - 10.1007/s15010-023-02068-x
DO - 10.1007/s15010-023-02068-x
M3 - Journal article
C2 - 37395924
AN - SCOPUS:85163856882
VL - 51
SP - 1739
EP - 1747
JO - Therapies
JF - Therapies
SN - 0300-8126
ER -
ID: 362696461