Recombinational DNA repair is regulated by compartmentalization of DNA lesions at the nuclear pore complex
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Recombinational DNA repair is regulated by compartmentalization of DNA lesions at the nuclear pore complex. / Géli, Vincent; Lisby, Michael.
I: BioEssays, Bind 37, Nr. 12, 2015, s. 1287-1292.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Recombinational DNA repair is regulated by compartmentalization of DNA lesions at the nuclear pore complex
AU - Géli, Vincent
AU - Lisby, Michael
PY - 2015
Y1 - 2015
N2 - The nuclear pore complex (NPC) is emerging as a center for recruitment of a class of "difficult to repair" lesions such as double-strand breaks without a repair template and eroded telomeres in telomerase-deficient cells. In addition to such pathological situations, a recent study by Su and colleagues shows that also physiological threats to genome integrity such as DNA secondary structure-forming triplet repeat sequences relocalize to the NPC during DNA replication. Mutants that fail to reposition the triplet repeat locus to the NPC cause repeat instability. Here, we review the types of DNA lesions that relocalize to the NPC, the putative mechanisms of relocalization, and the types of recombinational repair that are stimulated by the NPC, and present a model for NPC-facilitated repair.
AB - The nuclear pore complex (NPC) is emerging as a center for recruitment of a class of "difficult to repair" lesions such as double-strand breaks without a repair template and eroded telomeres in telomerase-deficient cells. In addition to such pathological situations, a recent study by Su and colleagues shows that also physiological threats to genome integrity such as DNA secondary structure-forming triplet repeat sequences relocalize to the NPC during DNA replication. Mutants that fail to reposition the triplet repeat locus to the NPC cause repeat instability. Here, we review the types of DNA lesions that relocalize to the NPC, the putative mechanisms of relocalization, and the types of recombinational repair that are stimulated by the NPC, and present a model for NPC-facilitated repair.
KW - DNA repair
KW - Homologous recombination
KW - Nuclear organization
KW - Nuclear pore complex
KW - Sumoylation
U2 - 10.1002/bies.201500084
DO - 10.1002/bies.201500084
M3 - Journal article
C2 - 26422820
AN - SCOPUS:84947492342
VL - 37
SP - 1287
EP - 1292
JO - BioEssays
JF - BioEssays
SN - 0265-9247
IS - 12
ER -
ID: 154363523