Recent advances in understanding autoimmune thyroid disease: the tallest tree in the forest of polyautoimmunity
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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Recent advances in understanding autoimmune thyroid disease : the tallest tree in the forest of polyautoimmunity. / Bliddal, Sofie; Nielsen, Claus Henrik; Feldt-Rasmussen, Ulla.
I: F1000Research, Bind 6, 1776, 2017.Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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TY - JOUR
T1 - Recent advances in understanding autoimmune thyroid disease
T2 - the tallest tree in the forest of polyautoimmunity
AU - Bliddal, Sofie
AU - Nielsen, Claus Henrik
AU - Feldt-Rasmussen, Ulla
PY - 2017
Y1 - 2017
N2 - Autoimmune thyroid disease (AITD) is often observed together with other autoimmune diseases. The coexistence of two or more autoimmune diseases in the same patient is referred to as polyautoimmunity, and AITD is the autoimmune disease most frequently involved. The occurrence of polyautoimmunity has led to the hypothesis that the affected patients suffer from a generalized dysregulation of their immune system. The present review summarizes recent discoveries unravelling the immunological mechanisms involved in autoimmunity, ranging from natural autoimmunity to disease-specific autoimmunity. Furthermore, the clinical grounds for considering AITD in a setting of polyautoimmunity are explored. A better understanding of these may pave the way for designing new treatment modalities targeting the underlying immune dysregulation when AITD appears in the context of polyautoimmunity.
AB - Autoimmune thyroid disease (AITD) is often observed together with other autoimmune diseases. The coexistence of two or more autoimmune diseases in the same patient is referred to as polyautoimmunity, and AITD is the autoimmune disease most frequently involved. The occurrence of polyautoimmunity has led to the hypothesis that the affected patients suffer from a generalized dysregulation of their immune system. The present review summarizes recent discoveries unravelling the immunological mechanisms involved in autoimmunity, ranging from natural autoimmunity to disease-specific autoimmunity. Furthermore, the clinical grounds for considering AITD in a setting of polyautoimmunity are explored. A better understanding of these may pave the way for designing new treatment modalities targeting the underlying immune dysregulation when AITD appears in the context of polyautoimmunity.
U2 - 10.12688/f1000research.11535.1
DO - 10.12688/f1000research.11535.1
M3 - Review
C2 - 29043075
VL - 6
JO - F1000Research
JF - F1000Research
SN - 2046-1402
M1 - 1776
ER -
ID: 196132093