Recent advances in understanding and managing contact dermatitis: 3 approved]
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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Recent advances in understanding and managing contact dermatitis : 3 approved]. / Martin, Stefan F.; Rustemeyer, Thomas; Thyssen, Jacob P.
I: F1000Research, Bind 7, 810, 2018.Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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TY - JOUR
T1 - Recent advances in understanding and managing contact dermatitis
T2 - 3 approved]
AU - Martin, Stefan F.
AU - Rustemeyer, Thomas
AU - Thyssen, Jacob P.
PY - 2018
Y1 - 2018
N2 - About 20% of the general population is contact-sensitized to common haptens such as fragrances, preservatives, and metals. Many also develop allergic contact dermatitis (ACD), the clinical manifestation of contact sensitization. ACD represents a common health issue and is also one of the most important occupational diseases. Although this inflammatory skin disease is mediated predominantly by memory T lymphocytes recognizing low-molecular-weight chemicals after skin contact, the innate immune system also plays an important role. Along that line, the presence of irritants may increase the risk of ACD and therefore ACD is often seen in the context of irritant contact dermatitis. In this review article, we discuss recent progress in basic research that has dramatically increased our understanding of the pathomechanisms of ACD and provides a basis for the development of novel diagnostic and therapeutic measures. Current methods for diagnosis as well as treatment options of ACD are also discussed.
AB - About 20% of the general population is contact-sensitized to common haptens such as fragrances, preservatives, and metals. Many also develop allergic contact dermatitis (ACD), the clinical manifestation of contact sensitization. ACD represents a common health issue and is also one of the most important occupational diseases. Although this inflammatory skin disease is mediated predominantly by memory T lymphocytes recognizing low-molecular-weight chemicals after skin contact, the innate immune system also plays an important role. Along that line, the presence of irritants may increase the risk of ACD and therefore ACD is often seen in the context of irritant contact dermatitis. In this review article, we discuss recent progress in basic research that has dramatically increased our understanding of the pathomechanisms of ACD and provides a basis for the development of novel diagnostic and therapeutic measures. Current methods for diagnosis as well as treatment options of ACD are also discussed.
KW - Chemical
KW - Contact dermatitis
KW - Skin
KW - Treatment
U2 - 10.12688/f1000research.13499.1
DO - 10.12688/f1000research.13499.1
M3 - Review
C2 - 29983912
AN - SCOPUS:85049121917
VL - 7
JO - F1000Research
JF - F1000Research
SN - 2046-1402
M1 - 810
ER -
ID: 218518052