Real-world data on melanoma brain metastases and survival outcome

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Standard

Real-world data on melanoma brain metastases and survival outcome. / Pedersen, Sidsel; Møller, Søren; Donia, Marco; Persson, Gitte Fredberg; Svane, Inge Marie; Ellebaek, Eva.

I: Melanoma Research, Bind 32, Nr. 3, 2022, s. 173-182.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Pedersen, S, Møller, S, Donia, M, Persson, GF, Svane, IM & Ellebaek, E 2022, 'Real-world data on melanoma brain metastases and survival outcome', Melanoma Research, bind 32, nr. 3, s. 173-182. https://doi.org/10.1097/CMR.0000000000000816

APA

Pedersen, S., Møller, S., Donia, M., Persson, G. F., Svane, I. M., & Ellebaek, E. (2022). Real-world data on melanoma brain metastases and survival outcome. Melanoma Research, 32(3), 173-182. https://doi.org/10.1097/CMR.0000000000000816

Vancouver

Pedersen S, Møller S, Donia M, Persson GF, Svane IM, Ellebaek E. Real-world data on melanoma brain metastases and survival outcome. Melanoma Research. 2022;32(3):173-182. https://doi.org/10.1097/CMR.0000000000000816

Author

Pedersen, Sidsel ; Møller, Søren ; Donia, Marco ; Persson, Gitte Fredberg ; Svane, Inge Marie ; Ellebaek, Eva. / Real-world data on melanoma brain metastases and survival outcome. I: Melanoma Research. 2022 ; Bind 32, Nr. 3. s. 173-182.

Bibtex

@article{b8a6e0c861164034b6b40a4ba70cbb47,

title = "Real-world data on melanoma brain metastases and survival outcome",

abstract = "Novel medical therapies have revolutionized outcome for patients with melanoma. However, patients with melanoma brain metastases (MBM) still have poor survival. Data are limited as these patients are generally excluded from clinical trials, wherefore real-world data on clinical outcome may support evidence-based treatment choices for patients with MBM. Patients diagnosed with MBM between 2008 and 2020 were included retrospectively. Patient characteristics, treatment, and outcome data were recorded from The Danish Metastatic Melanoma Database, pathology registries, electronic patient files, and radiation plans. Anti-programmed cell death protein 1 antibodies and the combination of BRAF/MEK-inhibitors were introduced in Denmark in 2015, and the cohort was split accordingly for comparison. A total of 527 patients were identified; 148 underwent surgical excision of MBM, 167 had stereotactic radiosurgery (SRS), 270 received whole-brain radiation therapy (WBRT), and 343 received systemic therapies. Median overall survival (mOS) for patients diagnosed with MBM before and after 2015 was 4.4 and 7.6 months, respectively. Patients receiving surgical excision as first choice of treatment had the best mOS of 10.9 months, whereas patients receiving WBRT had the worst outcome (mOS, 3.4 months). Postoperative SRS did not improve survival or local control after surgical excision of brain metastases. Of the 40 patients alive >3 years after diagnosis of MBM, 80% received immunotherapy at some point after diagnosis. Patients with meningeal carcinosis did not benefit from treatment with CPI. Outcome for patients with MBM has significantly improved after 2015, but long-term survivors are rare. Most patients alive >3 years after diagnosis of MBM received immunotherapy.",

keywords = "brain metastases, checkpoint inhibitors, immunotherapy, melanoma brain metastases, metastatic melanoma, stereotactic radiotherapy",

author = "Sidsel Pedersen and S{\o}ren M{\o}ller and Marco Donia and Persson, {Gitte Fredberg} and Svane, {Inge Marie} and Eva Ellebaek",

year = "2022",

doi = "10.1097/CMR.0000000000000816",

language = "English",

volume = "32",

pages = "173--182",

journal = "Melanoma Research",

issn = "0960-8931",

publisher = "Lippincott Williams & Wilkins, Ltd.",

number = "3",

}

RIS

TY - JOUR

T1 - Real-world data on melanoma brain metastases and survival outcome

AU - Pedersen, Sidsel

AU - Møller, Søren

AU - Donia, Marco

AU - Persson, Gitte Fredberg

AU - Svane, Inge Marie

AU - Ellebaek, Eva

PY - 2022

Y1 - 2022

N2 - Novel medical therapies have revolutionized outcome for patients with melanoma. However, patients with melanoma brain metastases (MBM) still have poor survival. Data are limited as these patients are generally excluded from clinical trials, wherefore real-world data on clinical outcome may support evidence-based treatment choices for patients with MBM. Patients diagnosed with MBM between 2008 and 2020 were included retrospectively. Patient characteristics, treatment, and outcome data were recorded from The Danish Metastatic Melanoma Database, pathology registries, electronic patient files, and radiation plans. Anti-programmed cell death protein 1 antibodies and the combination of BRAF/MEK-inhibitors were introduced in Denmark in 2015, and the cohort was split accordingly for comparison. A total of 527 patients were identified; 148 underwent surgical excision of MBM, 167 had stereotactic radiosurgery (SRS), 270 received whole-brain radiation therapy (WBRT), and 343 received systemic therapies. Median overall survival (mOS) for patients diagnosed with MBM before and after 2015 was 4.4 and 7.6 months, respectively. Patients receiving surgical excision as first choice of treatment had the best mOS of 10.9 months, whereas patients receiving WBRT had the worst outcome (mOS, 3.4 months). Postoperative SRS did not improve survival or local control after surgical excision of brain metastases. Of the 40 patients alive >3 years after diagnosis of MBM, 80% received immunotherapy at some point after diagnosis. Patients with meningeal carcinosis did not benefit from treatment with CPI. Outcome for patients with MBM has significantly improved after 2015, but long-term survivors are rare. Most patients alive >3 years after diagnosis of MBM received immunotherapy.

AB - Novel medical therapies have revolutionized outcome for patients with melanoma. However, patients with melanoma brain metastases (MBM) still have poor survival. Data are limited as these patients are generally excluded from clinical trials, wherefore real-world data on clinical outcome may support evidence-based treatment choices for patients with MBM. Patients diagnosed with MBM between 2008 and 2020 were included retrospectively. Patient characteristics, treatment, and outcome data were recorded from The Danish Metastatic Melanoma Database, pathology registries, electronic patient files, and radiation plans. Anti-programmed cell death protein 1 antibodies and the combination of BRAF/MEK-inhibitors were introduced in Denmark in 2015, and the cohort was split accordingly for comparison. A total of 527 patients were identified; 148 underwent surgical excision of MBM, 167 had stereotactic radiosurgery (SRS), 270 received whole-brain radiation therapy (WBRT), and 343 received systemic therapies. Median overall survival (mOS) for patients diagnosed with MBM before and after 2015 was 4.4 and 7.6 months, respectively. Patients receiving surgical excision as first choice of treatment had the best mOS of 10.9 months, whereas patients receiving WBRT had the worst outcome (mOS, 3.4 months). Postoperative SRS did not improve survival or local control after surgical excision of brain metastases. Of the 40 patients alive >3 years after diagnosis of MBM, 80% received immunotherapy at some point after diagnosis. Patients with meningeal carcinosis did not benefit from treatment with CPI. Outcome for patients with MBM has significantly improved after 2015, but long-term survivors are rare. Most patients alive >3 years after diagnosis of MBM received immunotherapy.

KW - brain metastases

KW - checkpoint inhibitors, immunotherapy

KW - melanoma brain metastases

KW - metastatic melanoma

KW - stereotactic radiotherapy

U2 - 10.1097/CMR.0000000000000816

DO - 10.1097/CMR.0000000000000816

M3 - Journal article

C2 - 35256571

AN - SCOPUS:85129780375

VL - 32

SP - 173

EP - 182

JO - Melanoma Research

JF - Melanoma Research

SN - 0960-8931

IS - 3

ER -

ID: 310958420