Rationale for and Development of the Pancreatic Quantitative Sensory Testing Consortium to Study Pain in Chronic Pancreatitis
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Rationale for and Development of the Pancreatic Quantitative Sensory Testing Consortium to Study Pain in Chronic Pancreatitis. / Phillips, Anna Evans; Faghih, Mahya; Singh, Vikesh K.; Olesen, Søren Schou; Kuhlmann, Louise; Novovic, Srdan; Bick, Benjamin; Hart, Philip A.; Ramsey, Mitchell L.; Talukdar, Rupjyoti; Garg, Pramod K.; Yadav, Dhiraj; Drewes, Asbjørn Mohr.
I: Pancreas, Bind 50, Nr. 9, 01.10.2021, s. 1298-1304.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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T1 - Rationale for and Development of the Pancreatic Quantitative Sensory Testing Consortium to Study Pain in Chronic Pancreatitis
AU - Phillips, Anna Evans
AU - Faghih, Mahya
AU - Singh, Vikesh K.
AU - Olesen, Søren Schou
AU - Kuhlmann, Louise
AU - Novovic, Srdan
AU - Bick, Benjamin
AU - Hart, Philip A.
AU - Ramsey, Mitchell L.
AU - Talukdar, Rupjyoti
AU - Garg, Pramod K.
AU - Yadav, Dhiraj
AU - Drewes, Asbjørn Mohr
PY - 2021/10/1
Y1 - 2021/10/1
N2 - Objectives Abdominal pain is the primary symptom of chronic pancreatitis (CP), but pain is difficult to assess, and objective methods for pain assessment are lacking. The characterization of the sensory component of pain as a surrogate for nociception can be achieved by sensory testing using standardized stimuli. Herein, we describe the rationale for and development of an international consortium to better understand and characterize CP pain.Methods A collaboration was initially formed between the University of Aalborg, Johns Hopkins University, and the University of Pittsburgh. This group refined the protocol for pancreatic quantitative sensory testing (P-QST) and then expanded the collaboration with plans for incorporating P-QST into prospective studies.Results The collaboration has successfully developed a P-QST nomogram. Chronic pancreatitis patients identified with P-QST as having widespread hyperalgesia had higher pain intensity scores, higher prevalence of constant pain, and decreased quality of life. Psychiatric comorbidities were independent of pain phenotypes. Multiple studies are underway to validate these findings and evaluate their utility in clinical trials.Conclusions Development of the P-QST Consortium will facilitate collaborative efforts to use P-QST as a means for evaluation and characterization of pain in CP patients, and optimize methods to guide individualized pain management approaches.
AB - Objectives Abdominal pain is the primary symptom of chronic pancreatitis (CP), but pain is difficult to assess, and objective methods for pain assessment are lacking. The characterization of the sensory component of pain as a surrogate for nociception can be achieved by sensory testing using standardized stimuli. Herein, we describe the rationale for and development of an international consortium to better understand and characterize CP pain.Methods A collaboration was initially formed between the University of Aalborg, Johns Hopkins University, and the University of Pittsburgh. This group refined the protocol for pancreatic quantitative sensory testing (P-QST) and then expanded the collaboration with plans for incorporating P-QST into prospective studies.Results The collaboration has successfully developed a P-QST nomogram. Chronic pancreatitis patients identified with P-QST as having widespread hyperalgesia had higher pain intensity scores, higher prevalence of constant pain, and decreased quality of life. Psychiatric comorbidities were independent of pain phenotypes. Multiple studies are underway to validate these findings and evaluate their utility in clinical trials.Conclusions Development of the P-QST Consortium will facilitate collaborative efforts to use P-QST as a means for evaluation and characterization of pain in CP patients, and optimize methods to guide individualized pain management approaches.
U2 - 10.1097/MPA.0000000000001912
DO - 10.1097/MPA.0000000000001912
M3 - Journal article
C2 - 34860815
VL - 50
SP - 1298
EP - 1304
JO - Pancreas
JF - Pancreas
SN - 0885-3177
IS - 9
ER -
ID: 303035514