Quantitative assessment of eosinophiluria in Schistosoma haematobium infections: a new marker of infection and bladder morbidity
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Standard
Quantitative assessment of eosinophiluria in Schistosoma haematobium infections : a new marker of infection and bladder morbidity. / Reimert, C M; Mshinda, H M; Hatz, C F; Kombe, Y; Nkulila, T; Poulsen, Lars K.; Christensen, N O; Vennervald, B J.
I: American Journal of Tropical Medicine and Hygiene, Bind 62, Nr. 1, 01.2000, s. 19-28.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Quantitative assessment of eosinophiluria in Schistosoma haematobium infections
T2 - a new marker of infection and bladder morbidity
AU - Reimert, C M
AU - Mshinda, H M
AU - Hatz, C F
AU - Kombe, Y
AU - Nkulila, T
AU - Poulsen, Lars K.
AU - Christensen, N O
AU - Vennervald, B J
PY - 2000/1
Y1 - 2000/1
N2 - Eosinophiluria, as quantified by measuring eosinophil cationic protein (ECP) in urinary extracts, microhematuria, egg excretion, and ultrasound-detectable bladder pathology were recorded in Schistosoma haematobium-infected Tanzanian school children at a baseline survey and during an 18-month post-treatment follow-up study. Significant correlations were seen between urinary ECP levels, intensity of infection, and bladder pathology. Treatment resulted in a marked reduction in prevalence and intensity of infection, in a delayed and less marked reduction in ECP levels, and in a resolution of pathology. The overall diagnostic efficiency of the ECP test (cut-off value for the ECP > or =5 ng/ml) in relation to infection was comparable with that of egg count and microhematuria, but with a better sensitivity than a single egg count. In relation to bladder pathology, the diagnostic performance of the ECP test (cut-off value for the ECP > or =25 ng/ml) exceeded that of a single egg count. In addition, the ECP was better in discriminating between different grades of bladder pathology. The present study points to the ECP as a useful marker of both S. haematobium infection and of associated bladder morbidity reflecting the inflammatory status of the bladder wall.
AB - Eosinophiluria, as quantified by measuring eosinophil cationic protein (ECP) in urinary extracts, microhematuria, egg excretion, and ultrasound-detectable bladder pathology were recorded in Schistosoma haematobium-infected Tanzanian school children at a baseline survey and during an 18-month post-treatment follow-up study. Significant correlations were seen between urinary ECP levels, intensity of infection, and bladder pathology. Treatment resulted in a marked reduction in prevalence and intensity of infection, in a delayed and less marked reduction in ECP levels, and in a resolution of pathology. The overall diagnostic efficiency of the ECP test (cut-off value for the ECP > or =5 ng/ml) in relation to infection was comparable with that of egg count and microhematuria, but with a better sensitivity than a single egg count. In relation to bladder pathology, the diagnostic performance of the ECP test (cut-off value for the ECP > or =25 ng/ml) exceeded that of a single egg count. In addition, the ECP was better in discriminating between different grades of bladder pathology. The present study points to the ECP as a useful marker of both S. haematobium infection and of associated bladder morbidity reflecting the inflammatory status of the bladder wall.
KW - Adolescent
KW - Animals
KW - Anthelmintics
KW - Blood Proteins
KW - Child
KW - Cohort Studies
KW - Enzyme-Linked Immunosorbent Assay
KW - Eosinophil Granule Proteins
KW - Eosinophils
KW - Female
KW - Follow-Up Studies
KW - Humans
KW - Inflammation Mediators
KW - Male
KW - Morbidity
KW - Parasite Egg Count
KW - Praziquantel
KW - Predictive Value of Tests
KW - Ribonucleases
KW - Schistosoma haematobium
KW - Schistosomiasis haematobia
KW - Statistics, Nonparametric
KW - Tanzania
KW - Urinary Bladder
KW - Urinary Bladder Diseases
KW - Urine
M3 - Journal article
C2 - 10761720
VL - 62
SP - 19
EP - 28
JO - Journal. National Malaria Society
JF - Journal. National Malaria Society
SN - 0002-9637
IS - 1
ER -
ID: 50846304