Pulmonary exposure to carbon black by inhalation or instillation in pregnant mice: effects on liver DNA strand breaks in dams and offspring
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Pulmonary exposure to carbon black by inhalation or instillation in pregnant mice : effects on liver DNA strand breaks in dams and offspring. / Jackson, Petra; Hougaard, Karin Sørig; Boisen, Anne Mette Zenner; Jacobsen, Nicklas Raun; Jensen, Keld Alstrup; Møller, Peter; Brunborg, Gunnar; Gutzkow, Kristine Bjerve; Andersen, Ole; Loft, Steffen; Vogel, Ulla Birgitte; Wallin, Håkan.
I: Nanotoxicology, Bind 6, Nr. 5, 08.2012, s. 486-500.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Pulmonary exposure to carbon black by inhalation or instillation in pregnant mice
T2 - effects on liver DNA strand breaks in dams and offspring
AU - Jackson, Petra
AU - Hougaard, Karin Sørig
AU - Boisen, Anne Mette Zenner
AU - Jacobsen, Nicklas Raun
AU - Jensen, Keld Alstrup
AU - Møller, Peter
AU - Brunborg, Gunnar
AU - Gutzkow, Kristine Bjerve
AU - Andersen, Ole
AU - Loft, Steffen
AU - Vogel, Ulla Birgitte
AU - Wallin, Håkan
PY - 2012/8
Y1 - 2012/8
N2 - Effects of maternal pulmonary exposure to carbon black (Printex 90) on gestation, lactation and DNA strand breaks were evaluated. Time-mated C57BL/6BomTac mice were exposed by inhalation to 42 mg/m(3) Printex 90 for 1 h/day on gestation days (GD) 8-18, or by four intratracheal instillations on GD 7, 10, 15 and 18, with total doses of 11, 54 and 268 µg/animal. Dams were monitored until weaning and some offspring until adolescence. Inflammation was assessed in maternal bronchoalveolar lavage (BAL) 3-5 days after exposure, and at weaning. Levels of DNA strand breaks were assessed in maternal BAL cells and liver, and in offspring liver. Persistent lung inflammation was observed in exposed mothers. Inhalation exposure induced more DNA strand breaks in the liver of mothers and their offspring, whereas intratracheal instillation did not. Neither inhalation nor instillation affected gestation and lactation. Maternal inhalation exposure to Printex 90-induced liver DNA damage in the mothers and the in utero exposed offspring.
AB - Effects of maternal pulmonary exposure to carbon black (Printex 90) on gestation, lactation and DNA strand breaks were evaluated. Time-mated C57BL/6BomTac mice were exposed by inhalation to 42 mg/m(3) Printex 90 for 1 h/day on gestation days (GD) 8-18, or by four intratracheal instillations on GD 7, 10, 15 and 18, with total doses of 11, 54 and 268 µg/animal. Dams were monitored until weaning and some offspring until adolescence. Inflammation was assessed in maternal bronchoalveolar lavage (BAL) 3-5 days after exposure, and at weaning. Levels of DNA strand breaks were assessed in maternal BAL cells and liver, and in offspring liver. Persistent lung inflammation was observed in exposed mothers. Inhalation exposure induced more DNA strand breaks in the liver of mothers and their offspring, whereas intratracheal instillation did not. Neither inhalation nor instillation affected gestation and lactation. Maternal inhalation exposure to Printex 90-induced liver DNA damage in the mothers and the in utero exposed offspring.
KW - Administration, Inhalation
KW - Animals
KW - Bronchoalveolar Lavage Fluid
KW - DNA Damage
KW - Drug-Induced Liver Injury
KW - Female
KW - Inhalation Exposure
KW - Lactation
KW - Liver
KW - Male
KW - Maternal Exposure
KW - Mice
KW - Mice, Inbred C57BL
KW - Nanoparticles
KW - Organ Size
KW - Pneumonia
KW - Pregnancy
KW - Soot
U2 - 10.3109/17435390.2011.587902
DO - 10.3109/17435390.2011.587902
M3 - Journal article
C2 - 21649560
VL - 6
SP - 486
EP - 500
JO - Nanotoxicology
JF - Nanotoxicology
SN - 1743-5390
IS - 5
ER -
ID: 45158626