Pubertal Onset in Girls is Strongly Influenced by Genetic Variation Affecting FSH Action
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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Pubertal Onset in Girls is Strongly Influenced by Genetic Variation Affecting FSH Action. / Hagen, Casper P; Sørensen, Kaspar; Aksglaede, Lise; Mouritsen, Annette; Mieritz, Mikkel G; Tinggaard, Jeanette; Wohlfahrt-Veje, Christine; Petersen, Jørgen Holm; Main, Katharina M.; Rajpert-De Meyts, Ewa; Almstrup, Kristian; Juul, Anders.
I: Scientific Reports, Bind 4, 6412, 09.2014, s. 1-6.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Pubertal Onset in Girls is Strongly Influenced by Genetic Variation Affecting FSH Action
AU - Hagen, Casper P
AU - Sørensen, Kaspar
AU - Aksglaede, Lise
AU - Mouritsen, Annette
AU - Mieritz, Mikkel G
AU - Tinggaard, Jeanette
AU - Wohlfahrt-Veje, Christine
AU - Petersen, Jørgen Holm
AU - Main, Katharina M.
AU - Rajpert-De Meyts, Ewa
AU - Almstrup, Kristian
AU - Juul, Anders
PY - 2014/9
Y1 - 2014/9
N2 - Age at pubertal onset varies substantially in healthy girls. Although genetic factors are responsible for more than half of the phenotypic variation, only a small part has been attributed to specific genetic polymorphisms identified so far. Follicle-stimulating hormone (FSH) stimulates ovarian follicle maturation and estradiol synthesis which is responsible for breast development. We assessed the effect of three polymorphisms influencing FSH action on age at breast deveopment in a population-based cohort of 964 healthy girls. Girls homozygous for FSHR -29AA (reduced FSH receptor expression) entered puberty 7.4 (2.5–12.4) months later than carriers of the common variants FSHR -29GG+GA, p = 0.003. To our knowledge, this is the strongest genetic effect on age at pubertal onset in girls published to date.
AB - Age at pubertal onset varies substantially in healthy girls. Although genetic factors are responsible for more than half of the phenotypic variation, only a small part has been attributed to specific genetic polymorphisms identified so far. Follicle-stimulating hormone (FSH) stimulates ovarian follicle maturation and estradiol synthesis which is responsible for breast development. We assessed the effect of three polymorphisms influencing FSH action on age at breast deveopment in a population-based cohort of 964 healthy girls. Girls homozygous for FSHR -29AA (reduced FSH receptor expression) entered puberty 7.4 (2.5–12.4) months later than carriers of the common variants FSHR -29GG+GA, p = 0.003. To our knowledge, this is the strongest genetic effect on age at pubertal onset in girls published to date.
U2 - 10.1038/srep06412
DO - 10.1038/srep06412
M3 - Journal article
VL - 4
SP - 1
EP - 6
JO - Scientific Reports
JF - Scientific Reports
SN - 2045-2322
M1 - 6412
ER -
ID: 140151451