PU.1 activates transcription of SHP-1 gene in hematopoietic cells.
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PU.1 activates transcription of SHP-1 gene in hematopoietic cells. / Wlodarski, Pawel; Zhang, Qian; Liu, Xiaobin; Kasprzycka, Monika; Marzec, Michal; Wasik, Mariusz A.
I: Journal of Biological Chemistry, Bind 282, Nr. 9, 2007, s. 6316-6323.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - PU.1 activates transcription of SHP-1 gene in hematopoietic cells.
AU - Wlodarski, Pawel
AU - Zhang, Qian
AU - Liu, Xiaobin
AU - Kasprzycka, Monika
AU - Marzec, Michal
AU - Wasik, Mariusz A.
N1 - M1 - Copyright (C) 2018 American Chemical Society (ACS). All Rights Reserved. CAPLUS AN 2007:204113(Journal)
PY - 2007
Y1 - 2007
N2 - Protein-tyrosine phosphatase SHP-1 is the key neg. regulator of numerous signaling pathways. SHP-1 is expressed in the hematopietic and epithelial cells as two structurally similar mRNA transcripts controlled by two different promoters designated P2 and P1, resp. Whereas the transcriptional regulation of the SHP-1 gene P1 promoter has been partially elucidated, the structure and functional control of the P2 promoter remain unknown despite the crit. role played by SHP-1 in the normal and malignant lymphoid and other hematopoetic cells. Using luciferase reporter assays with the set of constructs that contained a gradually truncated intron 1 of the SHP-1 gene, we identified the minimal (
AB - Protein-tyrosine phosphatase SHP-1 is the key neg. regulator of numerous signaling pathways. SHP-1 is expressed in the hematopietic and epithelial cells as two structurally similar mRNA transcripts controlled by two different promoters designated P2 and P1, resp. Whereas the transcriptional regulation of the SHP-1 gene P1 promoter has been partially elucidated, the structure and functional control of the P2 promoter remain unknown despite the crit. role played by SHP-1 in the normal and malignant lymphoid and other hematopoetic cells. Using luciferase reporter assays with the set of constructs that contained a gradually truncated intron 1 of the SHP-1 gene, we identified the minimal (
KW - SHP1 gene transcription activation PU1 hematopoietic cell
U2 - 10.1074/jbc.M607526200
DO - 10.1074/jbc.M607526200
M3 - Journal article
VL - 282
SP - 6316
EP - 6323
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
SN - 0021-9258
IS - 9
ER -
ID: 202375180