Psychotropic Drug Use in Acute Myeloid Leukaemia (AML) and Myelodysplastic Syndrome (MDS): A Danish Nationwide Matched Cohort Study of 2404 AML and 1307 MDS Patients
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Psychotropic Drug Use in Acute Myeloid Leukaemia (AML) and Myelodysplastic Syndrome (MDS) : A Danish Nationwide Matched Cohort Study of 2404 AML and 1307 MDS Patients. / Jensen, Oda; Øvlisen, Andreas Kiesbye; Jakobsen, Lasse Hjort; Roug, Anne Stidsholt; Nielsen, René Ernst; Marcher, Claus Werenberg; Ebbesen, Lene Hyldahl; Theilgaard-Mönch, Kim; Møller, Peter; Schöllkopf, Claudia; Torp-Pedersen, Christian; El-Galaly, Tarec Christoffer; Severinsen, Marianne Tang.
I: Clinical Epidemiology, Bind 14, 2022, s. 225-237.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Psychotropic Drug Use in Acute Myeloid Leukaemia (AML) and Myelodysplastic Syndrome (MDS)
T2 - A Danish Nationwide Matched Cohort Study of 2404 AML and 1307 MDS Patients
AU - Jensen, Oda
AU - Øvlisen, Andreas Kiesbye
AU - Jakobsen, Lasse Hjort
AU - Roug, Anne Stidsholt
AU - Nielsen, René Ernst
AU - Marcher, Claus Werenberg
AU - Ebbesen, Lene Hyldahl
AU - Theilgaard-Mönch, Kim
AU - Møller, Peter
AU - Schöllkopf, Claudia
AU - Torp-Pedersen, Christian
AU - El-Galaly, Tarec Christoffer
AU - Severinsen, Marianne Tang
N1 - © 2022 Jensen et al.
PY - 2022
Y1 - 2022
N2 - Introduction: The diagnosis of a life-threatening disease can lead to depression and anxiety resulting in pharmacological treatment. However, use of psychotropic drugs (antidepressants, anxiolytics, and antipsychotics) in acute myeloid leukaemia (AML) and myelodysplastic syndrome (MDS) is undetermined.Methods: Prescription of psychotropic drugs in Danish AML and MDS patients was compared to a cohort matched on age, sex, and country of origin from the Danish background population using national population-based registries.Results: In total, 2404 AML patients (median age 69 years) and 1307 MDS patients (median age 75 years) were included and each matched to five comparators from the background population. Two-year cumulative incidences showed that AML (20.6%) and MDS (21.2%) patients had a high risk of redemption of a psychotropic drug prescription compared to the background population (7.0% and 7.9%). High age, low educational level, and Charlson Comorbidity Index score ≥1 was associated with a higher risk in AML and MDS patients. Furthermore, non-curative treatment intent and performance status in AML patients, and high risk MDS were associated with elevated risk of psychotropic drug prescription.Conclusion: In conclusion, diagnoses of AML and MDS were associated with a higher rate of psychotropic drugs prescription compared to the background population.
AB - Introduction: The diagnosis of a life-threatening disease can lead to depression and anxiety resulting in pharmacological treatment. However, use of psychotropic drugs (antidepressants, anxiolytics, and antipsychotics) in acute myeloid leukaemia (AML) and myelodysplastic syndrome (MDS) is undetermined.Methods: Prescription of psychotropic drugs in Danish AML and MDS patients was compared to a cohort matched on age, sex, and country of origin from the Danish background population using national population-based registries.Results: In total, 2404 AML patients (median age 69 years) and 1307 MDS patients (median age 75 years) were included and each matched to five comparators from the background population. Two-year cumulative incidences showed that AML (20.6%) and MDS (21.2%) patients had a high risk of redemption of a psychotropic drug prescription compared to the background population (7.0% and 7.9%). High age, low educational level, and Charlson Comorbidity Index score ≥1 was associated with a higher risk in AML and MDS patients. Furthermore, non-curative treatment intent and performance status in AML patients, and high risk MDS were associated with elevated risk of psychotropic drug prescription.Conclusion: In conclusion, diagnoses of AML and MDS were associated with a higher rate of psychotropic drugs prescription compared to the background population.
U2 - 10.2147/CLEP.S336115
DO - 10.2147/CLEP.S336115
M3 - Journal article
C2 - 35241936
VL - 14
SP - 225
EP - 237
JO - Clinical Epidemiology
JF - Clinical Epidemiology
SN - 1179-1349
ER -
ID: 303373877