Psoriasis and adverse pregnancy outcomes: A nationwide case-control study in 491,274 women in Denmark
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Psoriasis and adverse pregnancy outcomes : A nationwide case-control study in 491,274 women in Denmark. / Johansen, Cæcilie Bachdal; Egeberg, Alexander; Jimenez-Solem, Espen; Skov, Lone; Thomsen, Simon Francis.
I: JAAD International, Bind 7, 2022, s. 146-155.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Psoriasis and adverse pregnancy outcomes
T2 - A nationwide case-control study in 491,274 women in Denmark
AU - Johansen, Cæcilie Bachdal
AU - Egeberg, Alexander
AU - Jimenez-Solem, Espen
AU - Skov, Lone
AU - Thomsen, Simon Francis
N1 - Publisher Copyright: © 2022 American Academy of Dermatology, Inc.
PY - 2022
Y1 - 2022
N2 - Background: The chronic systemic inflammation associated with psoriasis supposedly creates an undesirable milieu for a pregnancy, resulting in an increased risk of adverse pregnancy outcomes (APOs). Objective: To investigate the association between psoriasis and APOs as well as how the association differs according to psoriasis severity (mild and moderate-to-severe). Methods: This nationwide register-based case-control study collected data from 1973 to 2017. Cases were APOs (spontaneous abortion, ectopic pregnancy [EP], intrauterine fetal death, and stillbirth). Singleton live births were controls. Adjusted logistic regression models were used for statistical analyses. Results: In total, 42,041 (8.56%) APOs and 449,233 (91.44%) controls were included. EP was the only APO that was found to be statistically associated with psoriasis (odds ratio, 1.34; 95% CI, 1.06-1.68). Odds ratio for EP was the highest for women with moderate-to-severe psoriasis (odds ratio, 2.77; 95% CI, 1.13-6.76). The absolute risk of EP was 2.48% higher for women with moderate-to-severe psoriasis compared with women without psoriasis (3.98% vs 1.50%). Limitations: No access to clinical data confirming psoriasis severity. Conclusion: The present study found a significant association between EP and psoriasis (absolute risk of 3.98%). As EP is the leading cause of maternal morbidity and mortality in the first trimester of pregnancy, our findings call for particular care for women of reproductive age with psoriasis.
AB - Background: The chronic systemic inflammation associated with psoriasis supposedly creates an undesirable milieu for a pregnancy, resulting in an increased risk of adverse pregnancy outcomes (APOs). Objective: To investigate the association between psoriasis and APOs as well as how the association differs according to psoriasis severity (mild and moderate-to-severe). Methods: This nationwide register-based case-control study collected data from 1973 to 2017. Cases were APOs (spontaneous abortion, ectopic pregnancy [EP], intrauterine fetal death, and stillbirth). Singleton live births were controls. Adjusted logistic regression models were used for statistical analyses. Results: In total, 42,041 (8.56%) APOs and 449,233 (91.44%) controls were included. EP was the only APO that was found to be statistically associated with psoriasis (odds ratio, 1.34; 95% CI, 1.06-1.68). Odds ratio for EP was the highest for women with moderate-to-severe psoriasis (odds ratio, 2.77; 95% CI, 1.13-6.76). The absolute risk of EP was 2.48% higher for women with moderate-to-severe psoriasis compared with women without psoriasis (3.98% vs 1.50%). Limitations: No access to clinical data confirming psoriasis severity. Conclusion: The present study found a significant association between EP and psoriasis (absolute risk of 3.98%). As EP is the leading cause of maternal morbidity and mortality in the first trimester of pregnancy, our findings call for particular care for women of reproductive age with psoriasis.
KW - ectopic pregnancy
KW - fetal death
KW - pregnancy
KW - pregnancy outcome
KW - psoriasis
KW - psoriasis severity
KW - spontaneous abortion
KW - stillbirth
KW - women
U2 - 10.1016/j.jdin.2022.03.009
DO - 10.1016/j.jdin.2022.03.009
M3 - Journal article
C2 - 35497641
AN - SCOPUS:85128517323
VL - 7
SP - 146
EP - 155
JO - JAAD International
JF - JAAD International
SN - 2666-3287
ER -
ID: 306962324