Protein-based HDL subspecies: Rationale and association with cardiovascular disease, diabetes, stroke, and dementia
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Protein-based HDL subspecies : Rationale and association with cardiovascular disease, diabetes, stroke, and dementia. / Sacks, F. M.; Furtado, J. D.; Jensen, M. K.
I: B B A - Molecular and Cell Biology of Lipids, Bind 1867, Nr. 9, 159182, 2022.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Protein-based HDL subspecies
T2 - Rationale and association with cardiovascular disease, diabetes, stroke, and dementia
AU - Sacks, F. M.
AU - Furtado, J. D.
AU - Jensen, M. K.
PY - 2022
Y1 - 2022
N2 - HDL-cholesterol is associated with reduced risk of cardiovascular disease, and is used in clinical practice for risk stratification. HDL is composed of many protein-defined subspecies that each comprises just a few percent of the total, some associated with lower and some with higher risk of CVD. HDL that contains apoC3 or apoE are subspecies that have opposing actions on HDL reverse cholesterol transport and opposing associations with risk of future CVD, apoC3 adverse and apoE beneficial. In addition to coronary heart disease, HDL that contains apoC3 is associated with risk of future type 2 diabetes and insulin resistance; ischemic stroke and cerebral infarction; dementia and the deposition of beta-amyloid in the brain. HDL that contains apoE and apoE itself are associated with lower risk of dementia. Other HDL subspecies that contain complement C3, alpha-2 macroglobulin, plasminogen, or haptoglobin are associated with higher future risk of coronary heart disease, whereas others such as HDL that contains apoC1 are associated with lower risk. At this time, these findings provide improved understanding of the multifaceted HDL system to better determine risk and targeting of therapy for the most prevalent chronic lifestyle diseases in our society.
AB - HDL-cholesterol is associated with reduced risk of cardiovascular disease, and is used in clinical practice for risk stratification. HDL is composed of many protein-defined subspecies that each comprises just a few percent of the total, some associated with lower and some with higher risk of CVD. HDL that contains apoC3 or apoE are subspecies that have opposing actions on HDL reverse cholesterol transport and opposing associations with risk of future CVD, apoC3 adverse and apoE beneficial. In addition to coronary heart disease, HDL that contains apoC3 is associated with risk of future type 2 diabetes and insulin resistance; ischemic stroke and cerebral infarction; dementia and the deposition of beta-amyloid in the brain. HDL that contains apoE and apoE itself are associated with lower risk of dementia. Other HDL subspecies that contain complement C3, alpha-2 macroglobulin, plasminogen, or haptoglobin are associated with higher future risk of coronary heart disease, whereas others such as HDL that contains apoC1 are associated with lower risk. At this time, these findings provide improved understanding of the multifaceted HDL system to better determine risk and targeting of therapy for the most prevalent chronic lifestyle diseases in our society.
KW - HDL
KW - Proteomics
KW - Apolipoproteins C3 and E
KW - Cardiovascular disease
KW - Diabetes
KW - Dementia
KW - HIGH-DENSITY-LIPOPROTEIN
KW - CORONARY-ARTERY-DISEASE
KW - ESTER TRANSFER PROTEIN
KW - APOLIPOPROTEIN C-III
KW - PLASMA-LIPOPROTEINS
KW - ALZHEIMERS-DISEASE
KW - CHOLESTEROL EFFLUX
KW - PROTEOMIC ANALYSIS
KW - RISK
KW - BETA
U2 - 10.1016/j.bbalip.2022.159182
DO - 10.1016/j.bbalip.2022.159182
M3 - Journal article
C2 - 35605828
VL - 1867
JO - B B A - Molecular and Cell Biology of Lipids
JF - B B A - Molecular and Cell Biology of Lipids
SN - 1388-1981
IS - 9
M1 - 159182
ER -
ID: 337781447