Proposal for Updated Nomenclature and Classification of Potential Causative Mechanism in Patent Foramen Ovale-Associated Stroke
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Proposal for Updated Nomenclature and Classification of Potential Causative Mechanism in Patent Foramen Ovale-Associated Stroke. / Tobis, Jonathan M.; Elgendy, Akram Y.; Saver, Jeffrey L.; Amin, Zahid; Boudoulas, Konstantinos Dean; Carroll, John D.; Elgendy, Islam Y.; Grunwald, Iris Q.; Gertz, Zachary M.; Hijazi, Ziyad M.; Horlick, Eric M.; Kasner, Scott E.; Kent, David M.; Kumar, Preetham; Kavinsky, Clifford J.; Liebeskind, David S.; Lutsep, Helmi; Mojadidi, Mohammad K.; Messé, Steven R.; Mas, Jean Louis; Mattle, Heinrich P.; Meier, Bernhard; Mahmoud, Ahmad; Mahmoud, Ahmed N.; Nietlispach, Fabian; Patel, Nimesh K.; Rhodes, John F.; Reisman, Mark; Sommer, Robert J.; Sievert, Horst; Søndergaard, Lars; Zaman, Muhammad O.; Thaler, David.
I: JAMA Neurology, Bind 77, Nr. 7, 2020, s. 878-886.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Proposal for Updated Nomenclature and Classification of Potential Causative Mechanism in Patent Foramen Ovale-Associated Stroke
AU - Tobis, Jonathan M.
AU - Elgendy, Akram Y.
AU - Saver, Jeffrey L.
AU - Amin, Zahid
AU - Boudoulas, Konstantinos Dean
AU - Carroll, John D.
AU - Elgendy, Islam Y.
AU - Grunwald, Iris Q.
AU - Gertz, Zachary M.
AU - Hijazi, Ziyad M.
AU - Horlick, Eric M.
AU - Kasner, Scott E.
AU - Kent, David M.
AU - Kumar, Preetham
AU - Kavinsky, Clifford J.
AU - Liebeskind, David S.
AU - Lutsep, Helmi
AU - Mojadidi, Mohammad K.
AU - Messé, Steven R.
AU - Mas, Jean Louis
AU - Mattle, Heinrich P.
AU - Meier, Bernhard
AU - Mahmoud, Ahmad
AU - Mahmoud, Ahmed N.
AU - Nietlispach, Fabian
AU - Patel, Nimesh K.
AU - Rhodes, John F.
AU - Reisman, Mark
AU - Sommer, Robert J.
AU - Sievert, Horst
AU - Søndergaard, Lars
AU - Zaman, Muhammad O.
AU - Thaler, David
PY - 2020
Y1 - 2020
N2 - Importance: Recent epidemiologic and therapeutic advances have transformed understanding of the role of and therapeutic approach to patent foramen ovale (PFO) in ischemic stroke. Patent foramen ovale is likely responsible for approximately 5% of all ischemic strokes and 10% of those occurring in young and middle-aged adults. Observations: Randomized clinical trials have demonstrated that, to prevent recurrent ischemic stroke in patients with PFO and an otherwise-cryptogenic index ischemic stroke, PFO closure is superior to antiplatelet medical therapy alone; these trials have provided some evidence that, among medical therapy options, anticoagulants may be more effective than antiplatelet agents. Conclusions and Relevance: These new data indicate a need to update classification schemes of causative mechanisms in stroke, developed in an era in which an association between PFO and stroke was viewed as uncertain. We propose a revised general nomenclature and classification framework for PFO-associated stroke and detailed revisions for the 3 major stroke subtyping algorithms in wide use.
AB - Importance: Recent epidemiologic and therapeutic advances have transformed understanding of the role of and therapeutic approach to patent foramen ovale (PFO) in ischemic stroke. Patent foramen ovale is likely responsible for approximately 5% of all ischemic strokes and 10% of those occurring in young and middle-aged adults. Observations: Randomized clinical trials have demonstrated that, to prevent recurrent ischemic stroke in patients with PFO and an otherwise-cryptogenic index ischemic stroke, PFO closure is superior to antiplatelet medical therapy alone; these trials have provided some evidence that, among medical therapy options, anticoagulants may be more effective than antiplatelet agents. Conclusions and Relevance: These new data indicate a need to update classification schemes of causative mechanisms in stroke, developed in an era in which an association between PFO and stroke was viewed as uncertain. We propose a revised general nomenclature and classification framework for PFO-associated stroke and detailed revisions for the 3 major stroke subtyping algorithms in wide use.
UR - http://www.scopus.com/inward/record.url?scp=85083188518&partnerID=8YFLogxK
U2 - 10.1001/jamaneurol.2020.0458
DO - 10.1001/jamaneurol.2020.0458
M3 - Journal article
C2 - 32282016
AN - SCOPUS:85083188518
VL - 77
SP - 878
EP - 886
JO - JAMA Neurology
JF - JAMA Neurology
SN - 2168-6149
IS - 7
ER -
ID: 259987870