Prolonged lipopolysaccharide-induced illness elevates glucagon-like peptide-1 and suppresses peptide YY: A human-randomized cross-over trial
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Prolonged lipopolysaccharide-induced illness elevates glucagon-like peptide-1 and suppresses peptide YY : A human-randomized cross-over trial. / Brodersen, Katrine; Mose, Maike; Ramer Mikkelsen, Ulla; Jørgensen, Jens Otto Lunde; Festersen Nielsen, Michael; Møller, Niels; Wegeberg, Anne-Marie; Brock, Christina; Hartmann, Bolette; Holst, Jens Juul; Rittig, Nikolaj.
I: Physiological Reports, Bind 10, Nr. 18, e15462, 2022.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Prolonged lipopolysaccharide-induced illness elevates glucagon-like peptide-1 and suppresses peptide YY
T2 - A human-randomized cross-over trial
AU - Brodersen, Katrine
AU - Mose, Maike
AU - Ramer Mikkelsen, Ulla
AU - Jørgensen, Jens Otto Lunde
AU - Festersen Nielsen, Michael
AU - Møller, Niels
AU - Wegeberg, Anne-Marie
AU - Brock, Christina
AU - Hartmann, Bolette
AU - Holst, Jens Juul
AU - Rittig, Nikolaj
N1 - © 2022 The Authors. Physiological Reports published by Wiley Periodicals LLC on behalf of The Physiological Society and the American Physiological Society.
PY - 2022
Y1 - 2022
N2 - Severe systemic inflammation is associated with nausea, loss of appetite, and delayed gastric emptying, which increases hospitalization admission length and mortality rate. There is a lack of human controlled studies exploring gastric emptying rates and underlying mechanisms during inflammatory conditions. We aimed to investigate if systemic inflammation in young men delays gastro-intestinal transit times, lowers motility, and affects gastrointestinal hormone secretion. This substudy of a randomized crossover trial investigated eight healthy young men on two separate occasions; (I) following an overnight fast (healthy conditions/HC) and (II) fasting and bedrest combined with two lipopolysaccharide (LPS) injections of 1 ng kg-1 following an overnight fast and 0.5 ng kg-1 following another 24 h (systemic inflammation/SI). A standardized protein beverage and a SmartPill capsule (a wireless gastrointestinal monitoring system) were swallowed during each occasion. Whole gut transit time was comparable between HC and SI. SI decreased gastric mean pressure peak amplitude (p = 0.04) and increased pH rise across the pylorus and small bowel pH (p = 0.02) compared with HC. Glucagon-like peptide-1 was elevated during SI compared with HC (p = 0.04). Peptide YY was lower during SI compared with HC (p = 0.007). Prolonged LPS exposure combined with fasting and bedrest elevated glucagon-like peptide 1 concentrations, which may play a role for the nausea and loss of appetite typically associated with SI.
AB - Severe systemic inflammation is associated with nausea, loss of appetite, and delayed gastric emptying, which increases hospitalization admission length and mortality rate. There is a lack of human controlled studies exploring gastric emptying rates and underlying mechanisms during inflammatory conditions. We aimed to investigate if systemic inflammation in young men delays gastro-intestinal transit times, lowers motility, and affects gastrointestinal hormone secretion. This substudy of a randomized crossover trial investigated eight healthy young men on two separate occasions; (I) following an overnight fast (healthy conditions/HC) and (II) fasting and bedrest combined with two lipopolysaccharide (LPS) injections of 1 ng kg-1 following an overnight fast and 0.5 ng kg-1 following another 24 h (systemic inflammation/SI). A standardized protein beverage and a SmartPill capsule (a wireless gastrointestinal monitoring system) were swallowed during each occasion. Whole gut transit time was comparable between HC and SI. SI decreased gastric mean pressure peak amplitude (p = 0.04) and increased pH rise across the pylorus and small bowel pH (p = 0.02) compared with HC. Glucagon-like peptide-1 was elevated during SI compared with HC (p = 0.04). Peptide YY was lower during SI compared with HC (p = 0.007). Prolonged LPS exposure combined with fasting and bedrest elevated glucagon-like peptide 1 concentrations, which may play a role for the nausea and loss of appetite typically associated with SI.
KW - Cross-Over Studies
KW - Gastrointestinal Hormones
KW - Gastrointestinal Motility
KW - Glucagon-Like Peptide 1
KW - Humans
KW - Inflammation
KW - Lipopolysaccharides
KW - Male
KW - Nausea/chemically induced
KW - Peptide YY
U2 - 10.14814/phy2.15462
DO - 10.14814/phy2.15462
M3 - Journal article
C2 - 36117310
VL - 10
JO - Physiological Reports
JF - Physiological Reports
SN - 2051-817X
IS - 18
M1 - e15462
ER -
ID: 320663611