Prognostic value of18 f–fdg–pet parameters in patients with small cell lung cancer: A meta-analysis and review of current literature
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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Prognostic value of18 f–fdg–pet parameters in patients with small cell lung cancer : A meta-analysis and review of current literature. / Christensen, Tine Nøhr; Andersen, Per Kragh; Langer, Seppo W.; Fischer, Barbara Malene Bjerregaard.
I: Diagnostics, Bind 11, Nr. 2, 174, 2021.Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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TY - JOUR
T1 - Prognostic value of18 f–fdg–pet parameters in patients with small cell lung cancer
T2 - A meta-analysis and review of current literature
AU - Christensen, Tine Nøhr
AU - Andersen, Per Kragh
AU - Langer, Seppo W.
AU - Fischer, Barbara Malene Bjerregaard
N1 - Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2021
Y1 - 2021
N2 - Many studies have suggested a prognostic value of one or several positron emission tomography (PET) parameters in patients with small cell lung cancer (SCLC). However, studies are often small, and there is a considerable interstudy disagreement about which PET parameters have a prognostic value. The objective of this study was to perform a review and meta-analysis to identify the most promising PET parameter for prognostication. PubMed®, Cochrane, and Embase® were searched for papers addressing the prognostic value of any PET parameter at any treatment phase with any endpoint in patients with SCLC. Pooled hazard ratios (HRs) were calculated by a random effects model for the prognostic value of the baseline maximum standardized uptake value (SUVmax ) and metabolic tumor volume (MTV). The qualitative analysis included 38 studies, of these, 19 studies were included in the meta-analyses. The pooled results showed that high baseline MTV was prognostic for overall survival (OS) (HR: 2.83 (95% confidence interval [CI]: 2.00–4.01) and progression-free survival (PFS) (HR: 3.11 (95% CI: 1.99–4.90)). The prognostic value of SUVmax was less pronounced (OS: HR: 1.50 (95% CI: 1.17–1.91); PFS: HR: 1.24 (95% CI: 0.94–1.63)). Baseline MTV is a strong prognosticator for OS and PFS in patients with SCLC. MTV has a prognostic value superior to those of other PET parameters, but whether MTV is superior to other prognosticators of tumor burden needs further investigation.
AB - Many studies have suggested a prognostic value of one or several positron emission tomography (PET) parameters in patients with small cell lung cancer (SCLC). However, studies are often small, and there is a considerable interstudy disagreement about which PET parameters have a prognostic value. The objective of this study was to perform a review and meta-analysis to identify the most promising PET parameter for prognostication. PubMed®, Cochrane, and Embase® were searched for papers addressing the prognostic value of any PET parameter at any treatment phase with any endpoint in patients with SCLC. Pooled hazard ratios (HRs) were calculated by a random effects model for the prognostic value of the baseline maximum standardized uptake value (SUVmax ) and metabolic tumor volume (MTV). The qualitative analysis included 38 studies, of these, 19 studies were included in the meta-analyses. The pooled results showed that high baseline MTV was prognostic for overall survival (OS) (HR: 2.83 (95% confidence interval [CI]: 2.00–4.01) and progression-free survival (PFS) (HR: 3.11 (95% CI: 1.99–4.90)). The prognostic value of SUVmax was less pronounced (OS: HR: 1.50 (95% CI: 1.17–1.91); PFS: HR: 1.24 (95% CI: 0.94–1.63)). Baseline MTV is a strong prognosticator for OS and PFS in patients with SCLC. MTV has a prognostic value superior to those of other PET parameters, but whether MTV is superior to other prognosticators of tumor burden needs further investigation.
KW - FDG–PET/CT
KW - Metabolic tumor volume
KW - Prognosis
KW - Small cell lung cancer
KW - SUV
U2 - 10.3390/diagnostics11020174
DO - 10.3390/diagnostics11020174
M3 - Review
C2 - 33530446
AN - SCOPUS:85117066143
VL - 11
JO - Diagnostics
JF - Diagnostics
SN - 2075-4418
IS - 2
M1 - 174
ER -
ID: 291241711