TY - JOUR

T1 - Prognostic value of reading-to-reading blood pressure variability over 24 hours in 8938 subjects from 11 populations

AU - Hansen, Tine W

AU - Thijs, Lutgarde

AU - Li, Yan

AU - Boggia, José

AU - Kikuya, Masahiro

AU - Björklund-Bodegård, Kristina

AU - Richart, Tom

AU - Ohkubo, Takayoshi

AU - Jeppesen, Jørgen Lykke

AU - Torp-Pedersen, Christian

AU - Dolan, Eamon

AU - Kuznetsova, Tatiana

AU - Stolarz-Skrzypek, Katarzyna

AU - Tikhonoff, Valérie

AU - Malyutina, Sofia

AU - Casiglia, Edoardo

AU - Nikitin, Yuri

AU - Lind, Lars Solskov

AU - Sandoya, Edgardo

AU - Kawecka-Jaszcz, Kalina

AU - Imai, Yutaka

AU - Wang, Jiguang

AU - Ibsen, Hans

AU - O'Brien, Eoin

AU - Staessen, Jan A

AU - International Database on Ambulatory Blood Pressure in Relation to Cardiovascular Outcomes Investigators

AU - Li, Yan

PY - 2010/4/1

Y1 - 2010/4/1

N2 - In previous studies, of which several were underpowered, the relation between cardiovascular outcome and blood pressure (BP) variability was inconsistent. We followed health outcomes in 8938 subjects (mean age: 53.0 years; 46.8% women) randomly recruited from 11 populations. At baseline, we assessed BP variability from the SD and average real variability in 24-hour ambulatory BP recordings. We computed standardized hazard ratios (HRs) while stratifying by cohort and adjusting for 24-hour BP and other risk factors. Over 11.3 years (median), 1242 deaths (487 cardiovascular) occurred, and 1049, 577, 421, and 457 participants experienced a fatal or nonfatal cardiovascular, cardiac, or coronary event or a stroke. Higher diastolic average real variability in 24-hour ambulatory BP recordings predicted (Por=1.07) with the exception of cardiac and coronary events (HR: or=0.58). Higher systolic average real variability in 24-hour ambulatory BP recordings predicted (Por=1.07), with the exception of cardiac and coronary events (HR: or=0.54). SD predicted only total and cardiovascular mortality. While accounting for the 24-hour BP level, average real variability in 24-hour ambulatory BP recordings added

AB - In previous studies, of which several were underpowered, the relation between cardiovascular outcome and blood pressure (BP) variability was inconsistent. We followed health outcomes in 8938 subjects (mean age: 53.0 years; 46.8% women) randomly recruited from 11 populations. At baseline, we assessed BP variability from the SD and average real variability in 24-hour ambulatory BP recordings. We computed standardized hazard ratios (HRs) while stratifying by cohort and adjusting for 24-hour BP and other risk factors. Over 11.3 years (median), 1242 deaths (487 cardiovascular) occurred, and 1049, 577, 421, and 457 participants experienced a fatal or nonfatal cardiovascular, cardiac, or coronary event or a stroke. Higher diastolic average real variability in 24-hour ambulatory BP recordings predicted (Por=1.07) with the exception of cardiac and coronary events (HR: or=0.58). Higher systolic average real variability in 24-hour ambulatory BP recordings predicted (Por=1.07), with the exception of cardiac and coronary events (HR: or=0.54). SD predicted only total and cardiovascular mortality. While accounting for the 24-hour BP level, average real variability in 24-hour ambulatory BP recordings added

U2 - http://dx.doi.org/10.1161/HYPERTENSIONAHA.109.140798

DO - http://dx.doi.org/10.1161/HYPERTENSIONAHA.109.140798

M3 - Journal article

VL - 55

SP - 1049

EP - 1057

JO - Hypertension

JF - Hypertension

SN - 0194-911X

IS - 4

ER -