Prognostic scoring models in parotid gland carcinoma

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Dokumenter

  • Marie Westergaard-Nielsen
  • Møller, Søren
  • Christian Godballe
  • Jesper Grau Eriksen
  • Stine Rosenkilde Larsen
  • Katalin Kiss
  • Tina Agander
  • Benedicte Parm Ulhøi
  • Charabi, Birgitte Wittenborg
  • Tejs Ehlers Klug
  • Henrik Jacobsen
  • Jørgen Johansen
  • Claus Andrup Kristensen
  • Elo Andersen
  • Maria Andersen
  • Kristine Bjørndal

Background: The aim was to identify prognostic factors and test three prognostic scoring models that predicted the risk of recurrence in patients with parotid gland carcinoma. Methods: All Danish patients with parotid gland carcinoma, treated with curative intent, from 1990 to 2015 (n = 726) were included. Potential prognostic factors were evaluated using Cox regression and competing risk analyses. The concordance of each prognostic model was estimated using Harrel's C index. Results: The study population consisted of 344 men and 382 women, with a median age of 63 years. Age above 60 years, high grade histology, T3/T4 tumor, regional lymph node metastases, and involved surgical margins were all associated with a significant reduction in recurrence-free survival. The prognostic model that agreed best with actual outcomes had a C-index of 0.76. Conclusion: Prognostic scoring models may improve individualized follow-up strategies after curatively intended treatment for patients with parotid gland carcinoma.

OriginalsprogEngelsk
TidsskriftHead and Neck
Vol/bind43
Udgave nummer7
Sider (fra-til)2081-2090
Antal sider10
ISSN1043-3074
DOI
StatusUdgivet - jul. 2021

Bibliografisk note

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© 2021 Wiley Periodicals LLC.

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