Prognostic scoring models in parotid gland carcinoma
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Prognostic scoring models in parotid gland carcinoma. / Westergaard-Nielsen, Marie; Möller, Sören; Godballe, Christian; Grau Eriksen, Jesper; Larsen, Stine Rosenkilde; Kiss, Katalin; Agander, Tina; Parm Ulhøi, Benedicte; Charabi, Birgitte; Ehlers Klug, Tejs; Jacobsen, Henrik; Johansen, Jørgen; Kristensen, Claus Andrup; Andersen, Elo; Andersen, Maria; Bjørndal, Kristine.
I: Head and Neck, Bind 43, Nr. 7, 07.2021, s. 2081-2090.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Prognostic scoring models in parotid gland carcinoma
AU - Westergaard-Nielsen, Marie
AU - Möller, Sören
AU - Godballe, Christian
AU - Grau Eriksen, Jesper
AU - Larsen, Stine Rosenkilde
AU - Kiss, Katalin
AU - Agander, Tina
AU - Parm Ulhøi, Benedicte
AU - Charabi, Birgitte
AU - Ehlers Klug, Tejs
AU - Jacobsen, Henrik
AU - Johansen, Jørgen
AU - Kristensen, Claus Andrup
AU - Andersen, Elo
AU - Andersen, Maria
AU - Bjørndal, Kristine
N1 - Funding Information: This study was supported by the Danish Head and Neck Cancer Group (DAHANCA) and by Open Patient data Explorative Network (OPEN), Odense University Hospital, Denmark. Grants were provided from the University of Southern Denmark, the Region of Southern Denmark, the Danish Cancer Research Fund, and the Danish Cancer Society. Publisher Copyright: © 2021 Wiley Periodicals LLC.
PY - 2021/7
Y1 - 2021/7
N2 - Background: The aim was to identify prognostic factors and test three prognostic scoring models that predicted the risk of recurrence in patients with parotid gland carcinoma. Methods: All Danish patients with parotid gland carcinoma, treated with curative intent, from 1990 to 2015 (n = 726) were included. Potential prognostic factors were evaluated using Cox regression and competing risk analyses. The concordance of each prognostic model was estimated using Harrel's C index. Results: The study population consisted of 344 men and 382 women, with a median age of 63 years. Age above 60 years, high grade histology, T3/T4 tumor, regional lymph node metastases, and involved surgical margins were all associated with a significant reduction in recurrence-free survival. The prognostic model that agreed best with actual outcomes had a C-index of 0.76. Conclusion: Prognostic scoring models may improve individualized follow-up strategies after curatively intended treatment for patients with parotid gland carcinoma.
AB - Background: The aim was to identify prognostic factors and test three prognostic scoring models that predicted the risk of recurrence in patients with parotid gland carcinoma. Methods: All Danish patients with parotid gland carcinoma, treated with curative intent, from 1990 to 2015 (n = 726) were included. Potential prognostic factors were evaluated using Cox regression and competing risk analyses. The concordance of each prognostic model was estimated using Harrel's C index. Results: The study population consisted of 344 men and 382 women, with a median age of 63 years. Age above 60 years, high grade histology, T3/T4 tumor, regional lymph node metastases, and involved surgical margins were all associated with a significant reduction in recurrence-free survival. The prognostic model that agreed best with actual outcomes had a C-index of 0.76. Conclusion: Prognostic scoring models may improve individualized follow-up strategies after curatively intended treatment for patients with parotid gland carcinoma.
KW - follow-up
KW - parotid gland carcinoma
KW - prognosis
KW - prognostic scoring model
KW - recurrence risk
U2 - 10.1002/hed.26672
DO - 10.1002/hed.26672
M3 - Journal article
C2 - 33734517
AN - SCOPUS:85102637813
VL - 43
SP - 2081
EP - 2090
JO - Head & Neck (Print Edition)
JF - Head & Neck (Print Edition)
SN - 1043-3074
IS - 7
ER -
ID: 284090596