Prognostic implications of myocardial perfusion imaging by 82-rubidium positron emission tomography in male and female patients with angina and no perfusion defects

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Standard

Prognostic implications of myocardial perfusion imaging by 82-rubidium positron emission tomography in male and female patients with angina and no perfusion defects. / Rauf, Maira; Hansen, Kim W.; Galatius, Søren; Wiinberg, Niels; Brinth, Louise Scouborg; Højstrup, Signe; Talleruphuus, Ulrik; Prescott, Eva.

I: European Heart Journal Cardiovascular Imaging, Bind 24, Nr. 2, 2023, s. 212-222.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Rauf, M, Hansen, KW, Galatius, S, Wiinberg, N, Brinth, LS, Højstrup, S, Talleruphuus, U & Prescott, E 2023, 'Prognostic implications of myocardial perfusion imaging by 82-rubidium positron emission tomography in male and female patients with angina and no perfusion defects', European Heart Journal Cardiovascular Imaging, bind 24, nr. 2, s. 212-222. https://doi.org/10.1093/ehjci/jeac217

APA

Rauf, M., Hansen, K. W., Galatius, S., Wiinberg, N., Brinth, L. S., Højstrup, S., Talleruphuus, U., & Prescott, E. (2023). Prognostic implications of myocardial perfusion imaging by 82-rubidium positron emission tomography in male and female patients with angina and no perfusion defects. European Heart Journal Cardiovascular Imaging, 24(2), 212-222. https://doi.org/10.1093/ehjci/jeac217

Vancouver

Rauf M, Hansen KW, Galatius S, Wiinberg N, Brinth LS, Højstrup S o.a. Prognostic implications of myocardial perfusion imaging by 82-rubidium positron emission tomography in male and female patients with angina and no perfusion defects. European Heart Journal Cardiovascular Imaging. 2023;24(2):212-222. https://doi.org/10.1093/ehjci/jeac217

Author

Rauf, Maira ; Hansen, Kim W. ; Galatius, Søren ; Wiinberg, Niels ; Brinth, Louise Scouborg ; Højstrup, Signe ; Talleruphuus, Ulrik ; Prescott, Eva. / Prognostic implications of myocardial perfusion imaging by 82-rubidium positron emission tomography in male and female patients with angina and no perfusion defects. I: European Heart Journal Cardiovascular Imaging. 2023 ; Bind 24, Nr. 2. s. 212-222.

Bibtex

@article{40d8e86fd539476aa0a0b0487697f19c,

title = "Prognostic implications of myocardial perfusion imaging by 82-rubidium positron emission tomography in male and female patients with angina and no perfusion defects",

abstract = "Aims Myocardial perfusion imaging with 82-rubidium positron emission tomography (82Rb-PET) is increasingly used to assess stable coronary artery disease (CAD). We aimed to evaluate the prognostic value of82Rb-PET-derived parameters in patients with symptoms suggestive of CAD but no significant reversible or irreversible perfusion defects. Methods and results Among 3726 consecutive patients suspected of stable CAD who underwent82Rb-PET between January 2018 and August 2020, 2175 had no regional perfusion defects. Among these patients, we studied the association of82Rb-PET-derived parameters with a composite endpoint of all-cause mortality, hospitalization for unstable angina pectoris, acute myocardial infarction, heart failure, or ischaemic stroke. During a median follow up of 1.7 years (interquartile range 1.1–2.5 years), there were 148 endpoints. Myocardial blood flow (MBF) reserve (MFR), MBF during stress, left ventricular ejection fraction (LVEF), LVEF-reserve, heart rate reserve, and Ca score were associated with adverse outcomes. In multivariable Cox model adjusted for patient and82Rb-PET characteristics, MFR < 2 (hazard ratio (HR) 1.75, 95% confidence interval (CI) 1.24–2.48), LVEF (HR 1.38 per 10% decrease, 95% CI 1.24–1.54), and LVEF-reserve (HR 1.19 per 5% decrease, 95% CI 1.07–1.31) were significant predictors of endpoints. Results were consistent in subgroups defined by gender, history of ischaemic heart disease, low LVEF, and atrial fibrillation. Conclusion MFR, LVEF, and LVEF-reserve derived from82Rb-PET provide prognostic information on cardiovascular outcomes in patients with no perfusion defects. This may aid in identifying patients at risk and might provide an opportunity for preventive interventions.",

keywords = "coronary microvascular dysfunction, INOCA, myocardial blood flow reserve, positron emission tomography",

author = "Maira Rauf and Hansen, {Kim W.} and S{\o}ren Galatius and Niels Wiinberg and Brinth, {Louise Scouborg} and Signe H{\o}jstrup and Ulrik Talleruphuus and Eva Prescott",

year = "2023",

doi = "10.1093/ehjci/jeac217",

language = "English",

volume = "24",

pages = "212--222",

journal = "European Heart Journal Cardiovascular Imaging",

issn = "2047-2404",

publisher = "Oxford University Press",

number = "2",

}

RIS

TY - JOUR

T1 - Prognostic implications of myocardial perfusion imaging by 82-rubidium positron emission tomography in male and female patients with angina and no perfusion defects

AU - Rauf, Maira

AU - Hansen, Kim W.

AU - Galatius, Søren

AU - Wiinberg, Niels

AU - Brinth, Louise Scouborg

AU - Højstrup, Signe

AU - Talleruphuus, Ulrik

AU - Prescott, Eva

PY - 2023

Y1 - 2023

N2 - Aims Myocardial perfusion imaging with 82-rubidium positron emission tomography (82Rb-PET) is increasingly used to assess stable coronary artery disease (CAD). We aimed to evaluate the prognostic value of82Rb-PET-derived parameters in patients with symptoms suggestive of CAD but no significant reversible or irreversible perfusion defects. Methods and results Among 3726 consecutive patients suspected of stable CAD who underwent82Rb-PET between January 2018 and August 2020, 2175 had no regional perfusion defects. Among these patients, we studied the association of82Rb-PET-derived parameters with a composite endpoint of all-cause mortality, hospitalization for unstable angina pectoris, acute myocardial infarction, heart failure, or ischaemic stroke. During a median follow up of 1.7 years (interquartile range 1.1–2.5 years), there were 148 endpoints. Myocardial blood flow (MBF) reserve (MFR), MBF during stress, left ventricular ejection fraction (LVEF), LVEF-reserve, heart rate reserve, and Ca score were associated with adverse outcomes. In multivariable Cox model adjusted for patient and82Rb-PET characteristics, MFR < 2 (hazard ratio (HR) 1.75, 95% confidence interval (CI) 1.24–2.48), LVEF (HR 1.38 per 10% decrease, 95% CI 1.24–1.54), and LVEF-reserve (HR 1.19 per 5% decrease, 95% CI 1.07–1.31) were significant predictors of endpoints. Results were consistent in subgroups defined by gender, history of ischaemic heart disease, low LVEF, and atrial fibrillation. Conclusion MFR, LVEF, and LVEF-reserve derived from82Rb-PET provide prognostic information on cardiovascular outcomes in patients with no perfusion defects. This may aid in identifying patients at risk and might provide an opportunity for preventive interventions.

AB - Aims Myocardial perfusion imaging with 82-rubidium positron emission tomography (82Rb-PET) is increasingly used to assess stable coronary artery disease (CAD). We aimed to evaluate the prognostic value of82Rb-PET-derived parameters in patients with symptoms suggestive of CAD but no significant reversible or irreversible perfusion defects. Methods and results Among 3726 consecutive patients suspected of stable CAD who underwent82Rb-PET between January 2018 and August 2020, 2175 had no regional perfusion defects. Among these patients, we studied the association of82Rb-PET-derived parameters with a composite endpoint of all-cause mortality, hospitalization for unstable angina pectoris, acute myocardial infarction, heart failure, or ischaemic stroke. During a median follow up of 1.7 years (interquartile range 1.1–2.5 years), there were 148 endpoints. Myocardial blood flow (MBF) reserve (MFR), MBF during stress, left ventricular ejection fraction (LVEF), LVEF-reserve, heart rate reserve, and Ca score were associated with adverse outcomes. In multivariable Cox model adjusted for patient and82Rb-PET characteristics, MFR < 2 (hazard ratio (HR) 1.75, 95% confidence interval (CI) 1.24–2.48), LVEF (HR 1.38 per 10% decrease, 95% CI 1.24–1.54), and LVEF-reserve (HR 1.19 per 5% decrease, 95% CI 1.07–1.31) were significant predictors of endpoints. Results were consistent in subgroups defined by gender, history of ischaemic heart disease, low LVEF, and atrial fibrillation. Conclusion MFR, LVEF, and LVEF-reserve derived from82Rb-PET provide prognostic information on cardiovascular outcomes in patients with no perfusion defects. This may aid in identifying patients at risk and might provide an opportunity for preventive interventions.

KW - coronary microvascular dysfunction

KW - INOCA

KW - myocardial blood flow reserve

KW - positron emission tomography

U2 - 10.1093/ehjci/jeac217

DO - 10.1093/ehjci/jeac217

M3 - Journal article

C2 - 36394344

AN - SCOPUS:85147045349

VL - 24

SP - 212

EP - 222

JO - European Heart Journal Cardiovascular Imaging

JF - European Heart Journal Cardiovascular Imaging

SN - 2047-2404

IS - 2

ER -

ID: 366824692