Process for the manufacture of ajoene derivatives
Publikation: Patent
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Process for the manufacture of ajoene derivatives. / Bjarnsholt, Thomas (Opfinder); Hoeiby, Niels (Opfinder); Jensen, Peter Østrup (Opfinder); Phipps, Richard (Opfinder); Shanmugham, Meenakshi, Sundaram (Opfinder); Alhede, Maria (Opfinder); Hultqvist, Louise Dahl (Opfinder); Jakobsen, Tim Holm (Opfinder); Tanner, David (Opfinder); Larsen, Thomas, Ostenfeld (Opfinder); Givskov, Michael (Opfinder).
Patentnummer: WO2012076016. jun. 14, 2012.Publikation: Patent
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TY - PAT
T1 - Process for the manufacture of ajoene derivatives
AU - Bjarnsholt, Thomas
AU - Hoeiby,, Niels
AU - Jensen, Peter Østrup
AU - Phipps, Richard
AU - Shanmugham, Meenakshi, Sundaram
AU - Alhede, Maria
AU - Hultqvist, Louise Dahl
AU - Jakobsen, Tim Holm
AU - Tanner, David
AU - Larsen, Thomas, Ostenfeld
AU - Givskov,, Michael
PY - 2012/6/14
Y1 - 2012/6/14
N2 - The present invention relates to the compound (E,Z)-ajoene of formula (1) for use in treatment of bacterial infections. Another aspect of the present invention is a composition comprising (E,Z)-ajoene of formula (1) and at least one antibiotic. Yet another aspect of the invention relates to a method for manufacturing (E,Z) ajoene of formula (1) wherein the conformation of the internal C=C- bond can be either E or Z or a mixture thereof, said method comprising reacting allicin of formula (3) with an acid in the presence of a solvent to provide (E,Z ajoene) of formula (1) as defined above. Yet another aspect of the invention is (E,Z)-ajoene of formula 1 obtainable by the method described above.
AB - The present invention relates to the compound (E,Z)-ajoene of formula (1) for use in treatment of bacterial infections. Another aspect of the present invention is a composition comprising (E,Z)-ajoene of formula (1) and at least one antibiotic. Yet another aspect of the invention relates to a method for manufacturing (E,Z) ajoene of formula (1) wherein the conformation of the internal C=C- bond can be either E or Z or a mixture thereof, said method comprising reacting allicin of formula (3) with an acid in the presence of a solvent to provide (E,Z ajoene) of formula (1) as defined above. Yet another aspect of the invention is (E,Z)-ajoene of formula 1 obtainable by the method described above.
M3 - Patent
M1 - WO2012076016
ER -
ID: 180365289