Prevalence and Risk of Inflammatory Bowel Disease in Patients with Hidradenitis Suppurativa
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Standard
Prevalence and Risk of Inflammatory Bowel Disease in Patients with Hidradenitis Suppurativa. / Egeberg, Alexander; Jemec, Gregor B E; Kimball, Alexa B; Bachelez, Hervé; Gislason, Gunnar H; Thyssen, Jacob P; Mallbris, Lotus.
I: Journal of Investigative Dermatology, Bind 137, Nr. 5, 2017, s. 1060-1064.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Prevalence and Risk of Inflammatory Bowel Disease in Patients with Hidradenitis Suppurativa
AU - Egeberg, Alexander
AU - Jemec, Gregor B E
AU - Kimball, Alexa B
AU - Bachelez, Hervé
AU - Gislason, Gunnar H
AU - Thyssen, Jacob P
AU - Mallbris, Lotus
N1 - Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.
PY - 2017
Y1 - 2017
N2 - Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease. In small studies, inflammatory bowel disease has been associated with the increased prevalence of HS, but the data on the concurrence of inflammatory bowel disease in patients with HS are limited. We therefore investigated the prevalence and risk of inflammatory bowel disease in patients with HS compared with the general population. The study linked all Danish individuals aged ≥18 years in nationwide registers. Adjusted odds ratios and adjusted hazard ratios were estimated by logistic regression and Cox regression, respectively. The study comprised 7,732 patients with HS and 4,354,137 subjects from the general population. The prevalence (HS vs. general population) was 0.8% and 0.3% (odds ratio 2.04; 1.59-2.62) for Crohn's disease and 1.3% and 0.7% (odds ratio 1.75; 1.44-2.13) for ulcerative colitis. The risk of new-onset Crohn's disease (hazard ratio 2.19; 1.44-3.34) and ulcerative colitis (hazard ratio 1.63; 1.18-2.27) was significantly increased among patients with HS. In conclusion, HS was significantly associated with the presence and risk of new-onset inflammatory bowel disease, although the prevalence remained low. Gastrointestinal complaints in patients with HS should warrant further clinical examination.
AB - Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease. In small studies, inflammatory bowel disease has been associated with the increased prevalence of HS, but the data on the concurrence of inflammatory bowel disease in patients with HS are limited. We therefore investigated the prevalence and risk of inflammatory bowel disease in patients with HS compared with the general population. The study linked all Danish individuals aged ≥18 years in nationwide registers. Adjusted odds ratios and adjusted hazard ratios were estimated by logistic regression and Cox regression, respectively. The study comprised 7,732 patients with HS and 4,354,137 subjects from the general population. The prevalence (HS vs. general population) was 0.8% and 0.3% (odds ratio 2.04; 1.59-2.62) for Crohn's disease and 1.3% and 0.7% (odds ratio 1.75; 1.44-2.13) for ulcerative colitis. The risk of new-onset Crohn's disease (hazard ratio 2.19; 1.44-3.34) and ulcerative colitis (hazard ratio 1.63; 1.18-2.27) was significantly increased among patients with HS. In conclusion, HS was significantly associated with the presence and risk of new-onset inflammatory bowel disease, although the prevalence remained low. Gastrointestinal complaints in patients with HS should warrant further clinical examination.
KW - Adult
KW - Aged
KW - Colitis, Ulcerative/epidemiology
KW - Crohn Disease/epidemiology
KW - Denmark/epidemiology
KW - Female
KW - Follow-Up Studies
KW - Hidradenitis Suppurativa/complications
KW - Humans
KW - Logistic Models
KW - Male
KW - Middle Aged
KW - Prevalence
KW - Proportional Hazards Models
KW - Registries
KW - Risk Factors
U2 - 10.1016/j.jid.2016.11.040
DO - 10.1016/j.jid.2016.11.040
M3 - Journal article
C2 - 28089682
VL - 137
SP - 1060
EP - 1064
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
SN - 0022-202X
IS - 5
ER -
ID: 195501936