Preserved postprandial suppression of bone turnover markers, despite increased fasting levels, in postmenopausal women
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Preserved postprandial suppression of bone turnover markers, despite increased fasting levels, in postmenopausal women. / Abildgaard, Julie; Ploug, Thorkil; Pedersen, Anette Tonnes; Eiken, Pia; Pedersen, Bente Klarlund; Holst, Jens Juul; Hartmann, Bolette; Lindegaard, Birgitte.
I: Bone, Bind 143, 115612, 2021.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Preserved postprandial suppression of bone turnover markers, despite increased fasting levels, in postmenopausal women
AU - Abildgaard, Julie
AU - Ploug, Thorkil
AU - Pedersen, Anette Tonnes
AU - Eiken, Pia
AU - Pedersen, Bente Klarlund
AU - Holst, Jens Juul
AU - Hartmann, Bolette
AU - Lindegaard, Birgitte
PY - 2021
Y1 - 2021
N2 - Context: Menopause leads to an increased bone turnover associated with a high risk of fractures. Bone turnover is inhibited by meal intake, to some extent mediated by gut hormones, and interventions based on these endocrine changes may have potential in future prevention of osteoporosis.Objective: To investigate whether postmenopausal women exhibit postprandial suppression of bone turnover markers to the same extent as premenopausal women, despite higher fasting levels. Furthermore, to assess whether menopausal differences in bone turnover markers are related to postmenopausal changes in plasma gut hormone levels.Methods: A cross-sectional study of 21 premenopausal, 9 perimenopausal, and 24 postmenopausal women between 45 and 60 years of age. Serum/plasma levels of bone turnover markers and gut hormones were investigated during a 120 min oral glucose tolerance test. Bone turnover markers included N-terminal propeptide of type-I procollagen (PINP, bone formation marker) and carboxyterminal collagen I crosslinks (CTX-I, bone resorption marker). Gut hormone secretion was evaluated from responses of glucagon-like peptide-1 (GLP-1), glucagon-like peptide-2 (GLP-2) and glucose-dependent insulinotropic polypeptide (GIP).Results: Fasting levels of s-CTX-I were increased in periand postmenopausal women compared to premenopausal women (p = 0.001). Despite higher fasting levels, the relative postprandial s-CTX-I suppression was comparable across menopausal status (p = 0.14). Fasting levels of s-PINP were also increased in postmenopausal women compared to premenopausal women (p <0.001) with comparable and modest s-PINP suppression over menopause (p = 0.13). Postprandial plasma GLP-1 (p = 0.006) and GLP-2 (p = 0.01) were significantly increased in postmenopausal women compared to premenopausal women while GIP responses were slightly increased in the perimenopausal group (p = 0.02) but comparable between pre- and postmenopausal women. None of the postprandial gut hormone increases predicted postprandial bone turnover suppression in these women.Conclusions: Glucose-induced suppression of bone turnover markers is preserved in postmenopausal women, despite significantly higher fasting values, indicating that CTX-I lowering treatments based on these postprandial mechanisms might be a feasible strategy to prevent postmenopausal osteoporosis.
AB - Context: Menopause leads to an increased bone turnover associated with a high risk of fractures. Bone turnover is inhibited by meal intake, to some extent mediated by gut hormones, and interventions based on these endocrine changes may have potential in future prevention of osteoporosis.Objective: To investigate whether postmenopausal women exhibit postprandial suppression of bone turnover markers to the same extent as premenopausal women, despite higher fasting levels. Furthermore, to assess whether menopausal differences in bone turnover markers are related to postmenopausal changes in plasma gut hormone levels.Methods: A cross-sectional study of 21 premenopausal, 9 perimenopausal, and 24 postmenopausal women between 45 and 60 years of age. Serum/plasma levels of bone turnover markers and gut hormones were investigated during a 120 min oral glucose tolerance test. Bone turnover markers included N-terminal propeptide of type-I procollagen (PINP, bone formation marker) and carboxyterminal collagen I crosslinks (CTX-I, bone resorption marker). Gut hormone secretion was evaluated from responses of glucagon-like peptide-1 (GLP-1), glucagon-like peptide-2 (GLP-2) and glucose-dependent insulinotropic polypeptide (GIP).Results: Fasting levels of s-CTX-I were increased in periand postmenopausal women compared to premenopausal women (p = 0.001). Despite higher fasting levels, the relative postprandial s-CTX-I suppression was comparable across menopausal status (p = 0.14). Fasting levels of s-PINP were also increased in postmenopausal women compared to premenopausal women (p <0.001) with comparable and modest s-PINP suppression over menopause (p = 0.13). Postprandial plasma GLP-1 (p = 0.006) and GLP-2 (p = 0.01) were significantly increased in postmenopausal women compared to premenopausal women while GIP responses were slightly increased in the perimenopausal group (p = 0.02) but comparable between pre- and postmenopausal women. None of the postprandial gut hormone increases predicted postprandial bone turnover suppression in these women.Conclusions: Glucose-induced suppression of bone turnover markers is preserved in postmenopausal women, despite significantly higher fasting values, indicating that CTX-I lowering treatments based on these postprandial mechanisms might be a feasible strategy to prevent postmenopausal osteoporosis.
KW - Menopause
KW - Bone turnover
KW - Bone mineral density
KW - Gut hormones
KW - Glucose tolerance
KW - DEPENDENT INSULINOTROPIC POLYPEPTIDE
KW - MINERAL DENSITY
KW - RISK-FACTOR
KW - RESORPTION
KW - MENOPAUSE
KW - HORMONES
KW - FRACTURES
KW - METAANALYSIS
KW - POPULATION
U2 - 10.1016/j.bone.2020.115612
DO - 10.1016/j.bone.2020.115612
M3 - Journal article
C2 - 32853851
VL - 143
JO - Bone
JF - Bone
SN - 8756-3282
M1 - 115612
ER -
ID: 255683061