Preoperative multimodal prehabilitation before elective colorectal cancer surgery in patients with WHO performance status I or II: randomized clinical trial
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Preoperative multimodal prehabilitation before elective colorectal cancer surgery in patients with WHO performance status I or II : randomized clinical trial. / Bojesen, Rasmus Dahlin; Dalton, Susanne Oksbjerg; Skou, Søren Thorgaard; Jørgensen, Lars Bo; Walker, Line Rosell; Eriksen, Jens Ravn; Grube, Camilla; Justesen, Tobias Freyberg; Johansen, Christoffer; Slooter, Gerrit; Carli, Franco; Gögenur, Ismail.
I: BJS open, Bind 7, Nr. 6, zrad134, 2023.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Preoperative multimodal prehabilitation before elective colorectal cancer surgery in patients with WHO performance status I or II
T2 - randomized clinical trial
AU - Bojesen, Rasmus Dahlin
AU - Dalton, Susanne Oksbjerg
AU - Skou, Søren Thorgaard
AU - Jørgensen, Lars Bo
AU - Walker, Line Rosell
AU - Eriksen, Jens Ravn
AU - Grube, Camilla
AU - Justesen, Tobias Freyberg
AU - Johansen, Christoffer
AU - Slooter, Gerrit
AU - Carli, Franco
AU - Gögenur, Ismail
N1 - Publisher Copyright: © 2023 The Author(s).
PY - 2023
Y1 - 2023
N2 - Background: Multimodal prehabilitation is a promising adjunct to the current surgical treatment pathway for colorectal cancer patients to further improve postoperative outcomes, especially for high-risk patients with low functional capacity. The aim of the present study was to test the effect of prehabilitation on immediate postoperative recovery. Method: The study was designed as a RCT with two arms (intervention and control). The intervention consisted of 4 weeks of multimodal prehabilitation, with supervised physical training, nutritional support and medical optimization. The control group received standard of care. A total of 40 patients with colorectal cancer (WHO performance status I or II) undergoing elective surgery with curative intent were included. The primary outcome was postoperative recovery within the first 3 postoperative days, measured by Quality of Recovery-15, a validated questionnaire with a scoring range between 0 and 150 and a minimal clinically relevant difference of 8. Results: In total, 36 patients were analysed with 16 in the intervention group and 20 in the control group. The mean age of the included patients was 79 years. The overall treatment effect associated with the intervention was a 21.9 (95% c.i. 4.5-39.3) higher quality of recovery-15 score during the first 3 postoperative days compared to control, well above the minimal clinically relevant difference. Conclusion: Four weeks of multimodal prehabilitation prior to elective curative intended colorectal cancer surgery in patients with WHO performance status I or II was associated with a clinically relevant improvement in postoperative recovery. Registration number: NCT04167436 (http://www.clinicaltrials.gov).
AB - Background: Multimodal prehabilitation is a promising adjunct to the current surgical treatment pathway for colorectal cancer patients to further improve postoperative outcomes, especially for high-risk patients with low functional capacity. The aim of the present study was to test the effect of prehabilitation on immediate postoperative recovery. Method: The study was designed as a RCT with two arms (intervention and control). The intervention consisted of 4 weeks of multimodal prehabilitation, with supervised physical training, nutritional support and medical optimization. The control group received standard of care. A total of 40 patients with colorectal cancer (WHO performance status I or II) undergoing elective surgery with curative intent were included. The primary outcome was postoperative recovery within the first 3 postoperative days, measured by Quality of Recovery-15, a validated questionnaire with a scoring range between 0 and 150 and a minimal clinically relevant difference of 8. Results: In total, 36 patients were analysed with 16 in the intervention group and 20 in the control group. The mean age of the included patients was 79 years. The overall treatment effect associated with the intervention was a 21.9 (95% c.i. 4.5-39.3) higher quality of recovery-15 score during the first 3 postoperative days compared to control, well above the minimal clinically relevant difference. Conclusion: Four weeks of multimodal prehabilitation prior to elective curative intended colorectal cancer surgery in patients with WHO performance status I or II was associated with a clinically relevant improvement in postoperative recovery. Registration number: NCT04167436 (http://www.clinicaltrials.gov).
U2 - 10.1093/bjsopen/zrad134
DO - 10.1093/bjsopen/zrad134
M3 - Journal article
C2 - 38060453
AN - SCOPUS:85179900675
VL - 7
JO - BJS open
JF - BJS open
SN - 2474-9842
IS - 6
M1 - zrad134
ER -
ID: 396011080