Pregnancy Loss and Cardiovascular Diseases in Women: Recent Findings and Potential Mechanisms
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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Purpose of Review: Pregnancy loss (PL) has been acknowledged by the American Heart Association as a risk factor for cardiovascular diseases (CVD) later in life. This review aims to sum up recent findings (< ~ 5 years), concerning the link between PL and CVD. Recent Findings: The association between PL and risk of CVD increased with increasing number of PLs and is inversely correlated to maternal age, indicating that the association concerns euploid PLs. Likely mechanisms leading to PL and an increased risk of CVD include endothelial dysfunction, a pro-inflammatory state, antiphospholipid syndrome, autoimmunity, and genetic predisposition. Summary: PL as an independent risk factor for CVD constitutes an obvious gateway for a more targeted approach to future research, prevention, and treatment. Future research should clarify the following questions to which the answers are still unknown: whether PL is (a) directly causing the increased risk of CVD or (b) sharing pathophysiological mechanisms also leading to CVD.
Originalsprog | Engelsk |
---|---|
Tidsskrift | Current Atherosclerosis Reports |
Vol/bind | 24 |
Udgave nummer | 12 |
Sider (fra-til) | 889-899 |
Antal sider | 11 |
ISSN | 1523-3804 |
DOI | |
Status | Udgivet - 2022 |
Bibliografisk note
Funding Information:
Dr. Henriette Svarre Nielsen reports grants or contracts paid to her institution from Freya Biosciences ApS, Ferring Pharmaceuticals, BioInnovation Institute, Ministry of Education, Novo Nordisk Foundation, Augustinus Fonden, Oda og Hans Svenningsens Fond, Demant Fonden, Ole Kirks Fond, and Independent Research Fund Denmark. They also report payment or honoraria from Ferring Pharmaceuticals, Merck A/S, AstraZeneca, Cook Medical, and Ibsa Nordic.
Publisher Copyright:
© 2022, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
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