Prediction of allergenicity of gene-modified foods by serum-based testing
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Standard
Prediction of allergenicity of gene-modified foods by serum-based testing. / Poulsen, Lars K.
I: Annals of the New York Academy of Sciences, Bind 964, 05.2002, s. 185-96.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Prediction of allergenicity of gene-modified foods by serum-based testing
AU - Poulsen, Lars K.
PY - 2002/5
Y1 - 2002/5
N2 - On the basis of applying the IFBC/ILSI decision tree in a number of cases, a refinement of the scheme is suggested. Large differences in allergenic potential may be obtained by altering the route of administration of an allergen. Because an inhalation allergen can induce symptoms at different threshold doses depending on whether it is introduced via the inhalation or oral route, we propose that double-blind, placebo-controlled food challenges be performed in all cases of inhalation allergens being present in foods. Even proteins never previously ingested may cause IgE binding and elicit clinically relevant symptoms.
AB - On the basis of applying the IFBC/ILSI decision tree in a number of cases, a refinement of the scheme is suggested. Large differences in allergenic potential may be obtained by altering the route of administration of an allergen. Because an inhalation allergen can induce symptoms at different threshold doses depending on whether it is introduced via the inhalation or oral route, we propose that double-blind, placebo-controlled food challenges be performed in all cases of inhalation allergens being present in foods. Even proteins never previously ingested may cause IgE binding and elicit clinically relevant symptoms.
KW - Allergens
KW - Crops, Agricultural
KW - Food Hypersensitivity
KW - Humans
KW - Immunoglobulin E
KW - Placebos
KW - Plants, Genetically Modified
KW - Risk Factors
M3 - Journal article
C2 - 12023205
VL - 964
SP - 185
EP - 196
JO - Annals of The Lyceum of Natural History of New York
JF - Annals of The Lyceum of Natural History of New York
SN - 0077-8923
ER -
ID: 50845459