Potential of human saliva for nuclear magnetic resonance-based metabolomics and for health-related biomarker identification

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Standard

Potential of human saliva for nuclear magnetic resonance-based metabolomics and for health-related biomarker identification. / Bertram, Hanne Christine; Eggers, Nina; Eller, Nanna.

I: Analytical Chemistry, Bind 81, Nr. 21, 2009, s. 9188-93.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Bertram, HC, Eggers, N & Eller, N 2009, 'Potential of human saliva for nuclear magnetic resonance-based metabolomics and for health-related biomarker identification', Analytical Chemistry, bind 81, nr. 21, s. 9188-93. https://doi.org/10.1021/ac9020598

APA

Bertram, H. C., Eggers, N., & Eller, N. (2009). Potential of human saliva for nuclear magnetic resonance-based metabolomics and for health-related biomarker identification. Analytical Chemistry, 81(21), 9188-93. https://doi.org/10.1021/ac9020598

Vancouver

Bertram HC, Eggers N, Eller N. Potential of human saliva for nuclear magnetic resonance-based metabolomics and for health-related biomarker identification. Analytical Chemistry. 2009;81(21):9188-93. https://doi.org/10.1021/ac9020598

Author

Bertram, Hanne Christine ; Eggers, Nina ; Eller, Nanna. / Potential of human saliva for nuclear magnetic resonance-based metabolomics and for health-related biomarker identification. I: Analytical Chemistry. 2009 ; Bind 81, Nr. 21. s. 9188-93.

Bibtex

@article{bf63896088d411df928f000ea68e967b,
title = "Potential of human saliva for nuclear magnetic resonance-based metabolomics and for health-related biomarker identification",
abstract = "In the present study, the ability of (1)H nuclear magnetic resonance (NMR) for metabolic profiling of human saliva samples was investigated. High-resolution (1)H NMR spectra were obtained, and signals were assigned to various metabolites mainly representing small organic acids and amino acids. In addition, the use of human saliva for metabolomic studies was evaluated, and multivariate data analysis revealed that the 92 morning and night samples from 46 subjects could be discriminated with a predictability of 85%. The diurnal effect on the salivary metabolite profile were ascribed to changes in intensities of several metabolites including trimethylamine oxide (TMAO), choline, propionate, alanine, methanol, and N-acetyl groups. No effects of gender and body mass index (BMI) on the salivary metabolite profile were detected. The relationships between the salivary metabolome and glycated hemoglobin, systolic and diastolic blood pressure were investigated; however, no significant correlations could be established.",
author = "Bertram, {Hanne Christine} and Nina Eggers and Nanna Eller",
note = "Keywords: Biological Markers; Humans; Metabolomics; Nuclear Magnetic Resonance, Biomolecular; Principal Component Analysis; Saliva",
year = "2009",
doi = "10.1021/ac9020598",
language = "English",
volume = "81",
pages = "9188--93",
journal = "Industrial And Engineering Chemistry Analytical Edition",
issn = "0003-2700",
publisher = "American Chemical Society",
number = "21",

}

RIS

TY - JOUR

T1 - Potential of human saliva for nuclear magnetic resonance-based metabolomics and for health-related biomarker identification

AU - Bertram, Hanne Christine

AU - Eggers, Nina

AU - Eller, Nanna

N1 - Keywords: Biological Markers; Humans; Metabolomics; Nuclear Magnetic Resonance, Biomolecular; Principal Component Analysis; Saliva

PY - 2009

Y1 - 2009

N2 - In the present study, the ability of (1)H nuclear magnetic resonance (NMR) for metabolic profiling of human saliva samples was investigated. High-resolution (1)H NMR spectra were obtained, and signals were assigned to various metabolites mainly representing small organic acids and amino acids. In addition, the use of human saliva for metabolomic studies was evaluated, and multivariate data analysis revealed that the 92 morning and night samples from 46 subjects could be discriminated with a predictability of 85%. The diurnal effect on the salivary metabolite profile were ascribed to changes in intensities of several metabolites including trimethylamine oxide (TMAO), choline, propionate, alanine, methanol, and N-acetyl groups. No effects of gender and body mass index (BMI) on the salivary metabolite profile were detected. The relationships between the salivary metabolome and glycated hemoglobin, systolic and diastolic blood pressure were investigated; however, no significant correlations could be established.

AB - In the present study, the ability of (1)H nuclear magnetic resonance (NMR) for metabolic profiling of human saliva samples was investigated. High-resolution (1)H NMR spectra were obtained, and signals were assigned to various metabolites mainly representing small organic acids and amino acids. In addition, the use of human saliva for metabolomic studies was evaluated, and multivariate data analysis revealed that the 92 morning and night samples from 46 subjects could be discriminated with a predictability of 85%. The diurnal effect on the salivary metabolite profile were ascribed to changes in intensities of several metabolites including trimethylamine oxide (TMAO), choline, propionate, alanine, methanol, and N-acetyl groups. No effects of gender and body mass index (BMI) on the salivary metabolite profile were detected. The relationships between the salivary metabolome and glycated hemoglobin, systolic and diastolic blood pressure were investigated; however, no significant correlations could be established.

U2 - 10.1021/ac9020598

DO - 10.1021/ac9020598

M3 - Journal article

C2 - 19780580

VL - 81

SP - 9188

EP - 9193

JO - Industrial And Engineering Chemistry Analytical Edition

JF - Industrial And Engineering Chemistry Analytical Edition

SN - 0003-2700

IS - 21

ER -

ID: 20649587