Potential Clinical Impact of LAFOV PET/CT: A Systematic Evaluation of Image Quality and Lesion Detection
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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Potential Clinical Impact of LAFOV PET/CT : A Systematic Evaluation of Image Quality and Lesion Detection. / Honoré d’Este, Sabrina; Andersen, Flemming Littrup; Andersen, Julie Bjerglund; Jakobsen, Annika Loft; Sanchez Saxtoft, Eunice; Schulze, Christina; Hansen, Naja Liv; Andersen, Kim Francis; Reichkendler, Michala Holm; Højgaard, Liselotte; Fischer, Barbara Malene.
I: Diagnostics, Bind 13, Nr. 21, 3295, 2023.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Potential Clinical Impact of LAFOV PET/CT
T2 - A Systematic Evaluation of Image Quality and Lesion Detection
AU - Honoré d’Este, Sabrina
AU - Andersen, Flemming Littrup
AU - Andersen, Julie Bjerglund
AU - Jakobsen, Annika Loft
AU - Sanchez Saxtoft, Eunice
AU - Schulze, Christina
AU - Hansen, Naja Liv
AU - Andersen, Kim Francis
AU - Reichkendler, Michala Holm
AU - Højgaard, Liselotte
AU - Fischer, Barbara Malene
N1 - Publisher Copyright: © 2023 by the authors.
PY - 2023
Y1 - 2023
N2 - We performed a systematic evaluation of the diagnostic performance of LAFOV PET/CT with increasing acquisition time. The first 100 oncologic adult patients referred for 3 MBq/kg 2-[18F]fluoro-2-deoxy-D-glucose PET/CT on the Siemens Biograph Vision Quadra were included. A standard imaging protocol of 10 min was used and scans were reconstructed at 30 s, 60 s, 90 s, 180 s, 300 s, and 600 s. Paired comparisons of quantitative image noise, qualitative image quality, lesion detection, and lesion classification were performed. Image noise (n = 50, 34 women) was acceptable according to the current standard of care (coefficient-of-varianceref < 0.15) after 90 s and improved significantly with increasing acquisition time (PB < 0.001). The same was seen in observer rankings (PB < 0.001). Lesion detection (n = 100, 74 women) improved significantly from 30 s to 90 s (PB < 0.001), 90 s to 180 s (PB = 0.001), and 90 s to 300 s (PB = 0.002), while lesion classification improved from 90 s to 180 s (PB < 0.001), 180 s to 300 s (PB = 0.021), and 90 s to 300 s (PB < 0.001). We observed improved image quality, lesion detection, and lesion classification with increasing acquisition time while maintaining a total scan time of less than 5 min, which demonstrates a potential clinical benefit. Based on these results we recommend a standard imaging acquisition protocol for LAFOV PET/CT of minimum 180 s to maximum 300 s after injection of 3 MBq/kg 2-[18F]fluoro-2-deoxy-D-glucose.
AB - We performed a systematic evaluation of the diagnostic performance of LAFOV PET/CT with increasing acquisition time. The first 100 oncologic adult patients referred for 3 MBq/kg 2-[18F]fluoro-2-deoxy-D-glucose PET/CT on the Siemens Biograph Vision Quadra were included. A standard imaging protocol of 10 min was used and scans were reconstructed at 30 s, 60 s, 90 s, 180 s, 300 s, and 600 s. Paired comparisons of quantitative image noise, qualitative image quality, lesion detection, and lesion classification were performed. Image noise (n = 50, 34 women) was acceptable according to the current standard of care (coefficient-of-varianceref < 0.15) after 90 s and improved significantly with increasing acquisition time (PB < 0.001). The same was seen in observer rankings (PB < 0.001). Lesion detection (n = 100, 74 women) improved significantly from 30 s to 90 s (PB < 0.001), 90 s to 180 s (PB = 0.001), and 90 s to 300 s (PB = 0.002), while lesion classification improved from 90 s to 180 s (PB < 0.001), 180 s to 300 s (PB = 0.021), and 90 s to 300 s (PB < 0.001). We observed improved image quality, lesion detection, and lesion classification with increasing acquisition time while maintaining a total scan time of less than 5 min, which demonstrates a potential clinical benefit. Based on these results we recommend a standard imaging acquisition protocol for LAFOV PET/CT of minimum 180 s to maximum 300 s after injection of 3 MBq/kg 2-[18F]fluoro-2-deoxy-D-glucose.
KW - image quality
KW - lesion detection
KW - long-axial field-of-view (LAFOV)
KW - PET-CT
KW - quadra
KW - total-body PET
KW - whole-body PET
U2 - 10.3390/diagnostics13213295
DO - 10.3390/diagnostics13213295
M3 - Journal article
C2 - 37958190
AN - SCOPUS:85176440754
VL - 13
JO - Diagnostics
JF - Diagnostics
SN - 2075-4418
IS - 21
M1 - 3295
ER -
ID: 374645662