Postbiotics versus probiotics in early-onset colorectal cancer
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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Postbiotics versus probiotics in early-onset colorectal cancer. / Feizi, Hadi; Plotnikov, Andrey; Rezaee, Mohammad Ahangarzadeh; Ganbarov, Khudaverdi; Kamounah, Fadhil S.; Nikitin, Sergei; Kadkhoda, Hiva; Gholizadeh, Pourya; Pagliano, Pasquale; Kafil, Hossein Samadi.
I: Critical Reviews in Food Science and Nutrition, Bind 64, Nr. 11, 2024, s. 3573-3582.Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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TY - JOUR
T1 - Postbiotics versus probiotics in early-onset colorectal cancer
AU - Feizi, Hadi
AU - Plotnikov, Andrey
AU - Rezaee, Mohammad Ahangarzadeh
AU - Ganbarov, Khudaverdi
AU - Kamounah, Fadhil S.
AU - Nikitin, Sergei
AU - Kadkhoda, Hiva
AU - Gholizadeh, Pourya
AU - Pagliano, Pasquale
AU - Kafil, Hossein Samadi
N1 - Publisher Copyright: © 2022 Taylor & Francis Group, LLC.
PY - 2024
Y1 - 2024
N2 - Probiotics and postbiotics mechanisms of action and applications in early-onset colorectal cancer (EOCRC) prevention and treatment have significant importance but are a matter of debate and controversy. Therefore, in this review, we aimed to define the probiotics concept, advantages and limitations in comparison to postbiotics, and proposed mechanisms of anti-tumor action in EOCRC prevention and treatment of postbiotics. Biotics (probiotics, prebiotics, and postbiotics) could confer the health benefit by affecting the host gut microbiota directly and indirectly. The main mechanisms of action of probiotics in exerting anticancer features include immune system regulation, inhibition of cancer cell propagation, gut dysbiosis restoration, anticancer agents’ production, gut barrier function renovation, and cancer-promoting agents’ reduction. Postbiotics are suggested to have different mechanisms of action to restore eubiosis against EOCRC, including modulation of gut microbiota composition, gut microbial metabolites regulation, and intestinal barrier function improvement via different features such as immunomodulatory, anti-inflammatory, antioxidant, and anti-proliferative properties. A better understanding of postbiotics challenges and mechanism of action in therapeutic applications will allow us to sketch accurate trials in order to use postbiotics as bio-therapeutics in EOCRC.
AB - Probiotics and postbiotics mechanisms of action and applications in early-onset colorectal cancer (EOCRC) prevention and treatment have significant importance but are a matter of debate and controversy. Therefore, in this review, we aimed to define the probiotics concept, advantages and limitations in comparison to postbiotics, and proposed mechanisms of anti-tumor action in EOCRC prevention and treatment of postbiotics. Biotics (probiotics, prebiotics, and postbiotics) could confer the health benefit by affecting the host gut microbiota directly and indirectly. The main mechanisms of action of probiotics in exerting anticancer features include immune system regulation, inhibition of cancer cell propagation, gut dysbiosis restoration, anticancer agents’ production, gut barrier function renovation, and cancer-promoting agents’ reduction. Postbiotics are suggested to have different mechanisms of action to restore eubiosis against EOCRC, including modulation of gut microbiota composition, gut microbial metabolites regulation, and intestinal barrier function improvement via different features such as immunomodulatory, anti-inflammatory, antioxidant, and anti-proliferative properties. A better understanding of postbiotics challenges and mechanism of action in therapeutic applications will allow us to sketch accurate trials in order to use postbiotics as bio-therapeutics in EOCRC.
KW - Early-onset colorectal cancer (EOCRC)
KW - gut microbiota
KW - postbiotics
KW - prebiotics
KW - probiotics
U2 - 10.1080/10408398.2022.2132464
DO - 10.1080/10408398.2022.2132464
M3 - Review
C2 - 36250549
AN - SCOPUS:85139970167
VL - 64
SP - 3573
EP - 3582
JO - Critical Reviews in Food Science and Nutrition
JF - Critical Reviews in Food Science and Nutrition
SN - 1040-8398
IS - 11
ER -
ID: 389405897