Possible site of action of CGRP antagonists in migraine
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
The calcitonin gene-related peptide (CGRP) receptor antagonists olcegepant and telcagepant are very potent drugs. Both are effective in migraine but in doses much higher than would be predicted from receptor binding and other in vitro results. This could perhaps suggest an effect of CGRP antagonists behind the blood-brain barrier (BBB), i.e. in the central nervous system (CNS).
Originalsprog | Engelsk |
---|---|
Tidsskrift | Cephalalgia |
Vol/bind | 31 |
Udgave nummer | 6 |
Sider (fra-til) | 748-50 |
Antal sider | 3 |
ISSN | 0333-1024 |
DOI | |
Status | Udgivet - 2011 |
ID: 40186575