Possible site of action of CGRP antagonists in migraine
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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Possible site of action of CGRP antagonists in migraine. / Tfelt-Hansen, Peer; Olesen, Jes.
I: Cephalalgia, Bind 31, Nr. 6, 2011, s. 748-50.Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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TY - JOUR
T1 - Possible site of action of CGRP antagonists in migraine
AU - Tfelt-Hansen, Peer
AU - Olesen, Jes
PY - 2011
Y1 - 2011
N2 - The calcitonin gene-related peptide (CGRP) receptor antagonists olcegepant and telcagepant are very potent drugs. Both are effective in migraine but in doses much higher than would be predicted from receptor binding and other in vitro results. This could perhaps suggest an effect of CGRP antagonists behind the blood-brain barrier (BBB), i.e. in the central nervous system (CNS).
AB - The calcitonin gene-related peptide (CGRP) receptor antagonists olcegepant and telcagepant are very potent drugs. Both are effective in migraine but in doses much higher than would be predicted from receptor binding and other in vitro results. This could perhaps suggest an effect of CGRP antagonists behind the blood-brain barrier (BBB), i.e. in the central nervous system (CNS).
U2 - http://dx.doi.org/10.1177/0333102411398403
DO - http://dx.doi.org/10.1177/0333102411398403
M3 - Review
VL - 31
SP - 748
EP - 750
JO - Cephalalgia
JF - Cephalalgia
SN - 0800-1952
IS - 6
ER -
ID: 40186575