Polyphenol intake and differentiated thyroid cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

  • Raul Zamora-Ros
  • Valerie Cayssials
  • Silvia Franceschi
  • Cecilie Kyrø
  • Elisabete Weiderpass
  • Joakim Hennings
  • Maria Sandström
  • Anja Olsen
  • Kim Overvad
  • Marie Christine Boutron-Ruault
  • Thérèse Truong
  • Francesca Romana Mancini
  • Verena Katzke
  • Tilman Kühn
  • Heiner Boeing
  • Antonia Trichopoulou
  • Anna Karakatsani
  • Georgia Martimianaki
  • Domenico Palli
  • Vittorio Krogh
  • Salvatore Panico
  • Rosario Tumino
  • Carlotta Sacerdote
  • Cristina Lasheras
  • Miguel Rodríguez-Barranco
  • Pilar Amiano
  • Sandra M. Colorado-Yohar
  • Eva Ardanaz
  • Martin Almquist
  • Ulrika Ericson
  • H. Bas Bueno-de-Mesquita
  • Roel Vermeulen
  • Julie A. Schmidt
  • Graham Byrnes
  • Augustin Scalbert
  • Antonio Agudo
  • Sabina Rinaldi

Polyphenols are bioactive compounds with several anticarcinogenic activities; however, human data regarding associations with thyroid cancer (TC) is still negligible. Our aim was to evaluate the association between intakes of total, classes and subclasses of polyphenols and risk of differentiated TC and its main subtypes, papillary and follicular, in a European population. The European Prospective Investigation into Cancer and Nutrition cohort included 476,108 men and women from 10 European countries. During a mean follow-up of 14 years, there were 748 incident differentiated TC cases, including 601 papillary and 109 follicular tumors. Polyphenol intake was estimated at baseline using validated center/country-specific dietary questionnaires and the Phenol-Explorer database. In multivariable-adjusted Cox regression models, no association between total polyphenol and the risks of overall differentiated TC (HRQ4 vs. Q1 = 0.99, 95% confidence interval [CI] 0.77–1.29), papillary (HRQ4 vs. Q1 = 1.06, 95% CI 0.80–1.41) or follicular TC (HRQ4 vs. Q1 = 1.10, 95% CI 0.55–2.22) were found. No associations were observed either for flavonoids, phenolic acids or the rest of classes and subclasses of polyphenols. After stratification by body mass index (BMI), an inverse association between the intake of polyphenols (p-trend = 0.019) and phenolic acids (p-trend = 0.007) and differentiated TC risk in subjects with BMI ≥ 25 was observed. In conclusion, our study showed no associations between dietary polyphenol intake and differentiated TC risk; although further studies are warranted to investigate the potential protective associations in overweight and obese individuals.

OriginalsprogEngelsk
TidsskriftInternational Journal of Cancer
Vol/bind146
Udgave nummer7
Sider (fra-til)1841-1850
Antal sider10
ISSN0020-7136
DOI
StatusUdgivet - 2020
Eksternt udgivetJa

Bibliografisk note

Funding Information:
The authors thank Bertrand H?mon for his valuable help with the European Prospective Investigation into Cancer and Nutrition (EPIC) database. This study was supported by the Institute of Health Carlos III, Spain (CP15/00100), and cofounded by the European Regional Development Fund (ERDF) ?A way to build Europe.? The coordination of EPIC is financially supported by the European Commission (DG-SANCO) and the International Agency for Research on Cancer. The national cohorts are supported by Danish Cancer Society (Denmark); Ligue Contre le Cancer, Institut Gustave Roussy, Mutuelle G?n?rale de l'Education Nationale, Institut National de la Sant? et de la Recherche M?dicale (INSERM) (France); German Cancer Aid, German Cancer Research Center (DKFZ), Federal Ministry of Education and Research (BMBF), Deutsche Krebshilfe, Deutsches Krebsforschungszentrum and Federal Ministry of Education and Research (Germany); the Hellenic Health Foundation (Greece); Associazione Italiana per la Ricerca sul Cancro-AIRC-Italy and National Research Council (Italy); Dutch Ministry of Public Health, Welfare and Sports (VWS), Netherlands Cancer Registry (NKR), LK Research Funds, Dutch Prevention Funds, Dutch ZON (Zorg Onderzoek Nederland), World Cancer Research Fund (WCRF), Statistics Netherlands (The Netherlands); European Research Council (ERC-2009-AdG 232997); Health Research Fund (FIS): PI13/00061 to Granada; PI13/01162 to EPIC-Murcia, Regional Governments of Andaluc?a, Asturias, Basque Country, Murcia and Navarra, AGAUR - Generalitat de Catalunya (exp. 2014 SGR 726), The Health Research Funds RD12/0036/0018, cofounded by European Regional Development Fund (ERDF) ?A way to build Europe (Spain)?; Swedish Cancer Society, Swedish Research Council and County Councils of Sk?ne and V?sterbotten (Sweden); Cancer Research UK (14136 to EPIC-Norfolk; C570/A16491 and C8221/A19170 to EPIC-Oxford), Medical Research Council (1000143 to EPIC-Norfolk, MR/M012190/1 to EPIC-Oxford) (United Kingdom). We thank CERCA Programme/Generalitat de Catalunya for institutional support. R.Z.-R. was supported by the ?Miguel Servet? program (CP15/00100) from the Institute of Health Carlos III and European Social Fund (ESF).

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