Polyphenol intake and differentiated thyroid cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort
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Polyphenol intake and differentiated thyroid cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. / Zamora-Ros, Raul; Cayssials, Valerie; Franceschi, Silvia; Kyrø, Cecilie; Weiderpass, Elisabete; Hennings, Joakim; Sandström, Maria; Tjønneland, Anne; Olsen, Anja; Overvad, Kim; Boutron-Ruault, Marie Christine; Truong, Thérèse; Mancini, Francesca Romana; Katzke, Verena; Kühn, Tilman; Boeing, Heiner; Trichopoulou, Antonia; Karakatsani, Anna; Martimianaki, Georgia; Palli, Domenico; Krogh, Vittorio; Panico, Salvatore; Tumino, Rosario; Sacerdote, Carlotta; Lasheras, Cristina; Rodríguez-Barranco, Miguel; Amiano, Pilar; Colorado-Yohar, Sandra M.; Ardanaz, Eva; Almquist, Martin; Ericson, Ulrika; Bueno-de-Mesquita, H. Bas; Vermeulen, Roel; Schmidt, Julie A.; Byrnes, Graham; Scalbert, Augustin; Agudo, Antonio; Rinaldi, Sabina.
I: International Journal of Cancer, Bind 146, Nr. 7, 2020, s. 1841-1850.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Polyphenol intake and differentiated thyroid cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort
AU - Zamora-Ros, Raul
AU - Cayssials, Valerie
AU - Franceschi, Silvia
AU - Kyrø, Cecilie
AU - Weiderpass, Elisabete
AU - Hennings, Joakim
AU - Sandström, Maria
AU - Tjønneland, Anne
AU - Olsen, Anja
AU - Overvad, Kim
AU - Boutron-Ruault, Marie Christine
AU - Truong, Thérèse
AU - Mancini, Francesca Romana
AU - Katzke, Verena
AU - Kühn, Tilman
AU - Boeing, Heiner
AU - Trichopoulou, Antonia
AU - Karakatsani, Anna
AU - Martimianaki, Georgia
AU - Palli, Domenico
AU - Krogh, Vittorio
AU - Panico, Salvatore
AU - Tumino, Rosario
AU - Sacerdote, Carlotta
AU - Lasheras, Cristina
AU - Rodríguez-Barranco, Miguel
AU - Amiano, Pilar
AU - Colorado-Yohar, Sandra M.
AU - Ardanaz, Eva
AU - Almquist, Martin
AU - Ericson, Ulrika
AU - Bueno-de-Mesquita, H. Bas
AU - Vermeulen, Roel
AU - Schmidt, Julie A.
AU - Byrnes, Graham
AU - Scalbert, Augustin
AU - Agudo, Antonio
AU - Rinaldi, Sabina
N1 - Publisher Copyright: © 2019 UICC
PY - 2020
Y1 - 2020
N2 - Polyphenols are bioactive compounds with several anticarcinogenic activities; however, human data regarding associations with thyroid cancer (TC) is still negligible. Our aim was to evaluate the association between intakes of total, classes and subclasses of polyphenols and risk of differentiated TC and its main subtypes, papillary and follicular, in a European population. The European Prospective Investigation into Cancer and Nutrition cohort included 476,108 men and women from 10 European countries. During a mean follow-up of 14 years, there were 748 incident differentiated TC cases, including 601 papillary and 109 follicular tumors. Polyphenol intake was estimated at baseline using validated center/country-specific dietary questionnaires and the Phenol-Explorer database. In multivariable-adjusted Cox regression models, no association between total polyphenol and the risks of overall differentiated TC (HRQ4 vs. Q1 = 0.99, 95% confidence interval [CI] 0.77–1.29), papillary (HRQ4 vs. Q1 = 1.06, 95% CI 0.80–1.41) or follicular TC (HRQ4 vs. Q1 = 1.10, 95% CI 0.55–2.22) were found. No associations were observed either for flavonoids, phenolic acids or the rest of classes and subclasses of polyphenols. After stratification by body mass index (BMI), an inverse association between the intake of polyphenols (p-trend = 0.019) and phenolic acids (p-trend = 0.007) and differentiated TC risk in subjects with BMI ≥ 25 was observed. In conclusion, our study showed no associations between dietary polyphenol intake and differentiated TC risk; although further studies are warranted to investigate the potential protective associations in overweight and obese individuals.
AB - Polyphenols are bioactive compounds with several anticarcinogenic activities; however, human data regarding associations with thyroid cancer (TC) is still negligible. Our aim was to evaluate the association between intakes of total, classes and subclasses of polyphenols and risk of differentiated TC and its main subtypes, papillary and follicular, in a European population. The European Prospective Investigation into Cancer and Nutrition cohort included 476,108 men and women from 10 European countries. During a mean follow-up of 14 years, there were 748 incident differentiated TC cases, including 601 papillary and 109 follicular tumors. Polyphenol intake was estimated at baseline using validated center/country-specific dietary questionnaires and the Phenol-Explorer database. In multivariable-adjusted Cox regression models, no association between total polyphenol and the risks of overall differentiated TC (HRQ4 vs. Q1 = 0.99, 95% confidence interval [CI] 0.77–1.29), papillary (HRQ4 vs. Q1 = 1.06, 95% CI 0.80–1.41) or follicular TC (HRQ4 vs. Q1 = 1.10, 95% CI 0.55–2.22) were found. No associations were observed either for flavonoids, phenolic acids or the rest of classes and subclasses of polyphenols. After stratification by body mass index (BMI), an inverse association between the intake of polyphenols (p-trend = 0.019) and phenolic acids (p-trend = 0.007) and differentiated TC risk in subjects with BMI ≥ 25 was observed. In conclusion, our study showed no associations between dietary polyphenol intake and differentiated TC risk; although further studies are warranted to investigate the potential protective associations in overweight and obese individuals.
KW - cohort
KW - EPIC
KW - flavonoids
KW - intake
KW - polyphenols
KW - thyroid cancer
U2 - 10.1002/ijc.32589
DO - 10.1002/ijc.32589
M3 - Journal article
C2 - 31342519
AN - SCOPUS:85070923942
VL - 146
SP - 1841
EP - 1850
JO - Acta - Unio Internationalis Contra Cancrum
JF - Acta - Unio Internationalis Contra Cancrum
SN - 0898-6924
IS - 7
ER -
ID: 286486917