Plasma levels of mannose-binding lectin and future risk of venous thromboembolism
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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Plasma levels of mannose-binding lectin and future risk of venous thromboembolism. / Liang, Robin A.; Høiland, Ina I.; Ueland, Thor; Aukrust, Pål; Snir, Omri; Hindberg, Kristian; Brækkan, Sigrid K.; Garred, Peter; Mollnes, Tom E.; Hansen, John Bjarne.
I: Journal of Thrombosis and Haemostasis, Bind 17, Nr. 10, 2019, s. 1661-1669.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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T1 - Plasma levels of mannose-binding lectin and future risk of venous thromboembolism
AU - Liang, Robin A.
AU - Høiland, Ina I.
AU - Ueland, Thor
AU - Aukrust, Pål
AU - Snir, Omri
AU - Hindberg, Kristian
AU - Brækkan, Sigrid K.
AU - Garred, Peter
AU - Mollnes, Tom E.
AU - Hansen, John Bjarne
PY - 2019
Y1 - 2019
N2 - Background: Animal and observational studies have suggested a pathophysiological role for complement in venous thromboembolism (VTE), but the initiating mechanisms are unknown. Mannose-binding lectin (MBL) bound to altered host cells leads to activation of the lectin complement pathway, and both high and low MBL levels have been implicated in the pathophysiology of cardiovascular disease. Objectives: To investigate the association between plasma MBL levels and future risk of incident VTE. Methods: We conducted a nested case-control study in 417 VTE patients and 849 age-matched and sex-matched controls derived from the general population (Tromsø Study). Plasma MBL levels were measured using enzyme-linked immunosorbent assay. Logistic regression models were used to estimate odds ratio (OR) for VTE across quartiles of plasma MBL levels. Results: Subjects with plasma MBL levels in the lowest quartile (<435 ng/mL) had a reduced OR for overall VTE (OR 0.79, 95% confidence interval [CI]: 0.56-1.10) and for DVT (OR 0.70, 95% CI: 0.47-1.04) compared to those with MBL in the highest quartile (≥2423 ng/mL) after multivariable adjustments. For VTE, DVT, and pulmonary embolism (PE) the ORs decreased substantially with decreasing time between blood sampling and VTE event. Conclusions: Our findings suggest that low plasma MBL levels are associated with reduced risk of VTE, and DVT in particular.
AB - Background: Animal and observational studies have suggested a pathophysiological role for complement in venous thromboembolism (VTE), but the initiating mechanisms are unknown. Mannose-binding lectin (MBL) bound to altered host cells leads to activation of the lectin complement pathway, and both high and low MBL levels have been implicated in the pathophysiology of cardiovascular disease. Objectives: To investigate the association between plasma MBL levels and future risk of incident VTE. Methods: We conducted a nested case-control study in 417 VTE patients and 849 age-matched and sex-matched controls derived from the general population (Tromsø Study). Plasma MBL levels were measured using enzyme-linked immunosorbent assay. Logistic regression models were used to estimate odds ratio (OR) for VTE across quartiles of plasma MBL levels. Results: Subjects with plasma MBL levels in the lowest quartile (<435 ng/mL) had a reduced OR for overall VTE (OR 0.79, 95% confidence interval [CI]: 0.56-1.10) and for DVT (OR 0.70, 95% CI: 0.47-1.04) compared to those with MBL in the highest quartile (≥2423 ng/mL) after multivariable adjustments. For VTE, DVT, and pulmonary embolism (PE) the ORs decreased substantially with decreasing time between blood sampling and VTE event. Conclusions: Our findings suggest that low plasma MBL levels are associated with reduced risk of VTE, and DVT in particular.
KW - complement
KW - deep vein thrombosis
KW - mannose-binding lectin
KW - pulmonary embolism
KW - venous thromboembolism
U2 - 10.1111/jth.14539
DO - 10.1111/jth.14539
M3 - Journal article
C2 - 31220397
AN - SCOPUS:85068354624
VL - 17
SP - 1661
EP - 1669
JO - Journal of Thrombosis and Haemostasis
JF - Journal of Thrombosis and Haemostasis
SN - 1538-7933
IS - 10
ER -
ID: 236218638