Plasma levels of glucagon but not GLP-1 are elevated in response to inflammation in humans
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Plasma levels of glucagon but not GLP-1 are elevated in response to inflammation in humans. / Modrzynska, Justyna; Klein, Christine F; Iversen, Kasper; Bundgaard, Henning; Hartmann, Bolette; Mose, Maike; Rittig, Nikolaj; Møller, Niels; Holst, Jens J; Wewer Albrechtsen, Nicolai J.
I: Endocrine Connections, Bind 10, Nr. 2, 2021, s. 205-213.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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T1 - Plasma levels of glucagon but not GLP-1 are elevated in response to inflammation in humans
AU - Modrzynska, Justyna
AU - Klein, Christine F
AU - Iversen, Kasper
AU - Bundgaard, Henning
AU - Hartmann, Bolette
AU - Mose, Maike
AU - Rittig, Nikolaj
AU - Møller, Niels
AU - Holst, Jens J
AU - Wewer Albrechtsen, Nicolai J
PY - 2021
Y1 - 2021
N2 - Objective: Glucagon and glucagon-like peptide-1 (GLP-1) originate from the common precursor, proglucagon, and their plasma concentrations have been reported to be increased during inflammatory conditions. Increased blood glucose levels are frequently observed in septic patients, and therefore we hypothesized that glucagon, but not GLP-1, is increased in individuals with inflammation.Design: Prospective longitudinal cohort study.Materials and methods: We measured glucagon and GLP-1 in plasma sampled consecutively in three cohorts consisting of patients with infective endocarditis (n = 16), urosepsis (n = 28) and post-operative inflammation following percutaneous aortic valve implantation or thoracic endovascular aortic repair (n = 5). Correlations between C-reactive protein (CRP), a marker of systemic inflammation, and glucagon and GLP-1 concentrations were investigated. Additionally, glucagon and GLP-1 concentrations were measured after a bolus infusion of lipopolysaccharide (LPS, 1 ng/kg) in nine healthy young males.Results: Glucagon and CRP were positively and significantly correlated (r = 0.27; P = 0.0003), whereas no significant association between GLP-1 and CRP was found (r = 0.08, P = 0.30). LPS infusion resulted in acute systemic inflammation reflected by increased temperature, pulse, tumor necrosis factor-α (TNFα), interleukin-6 (IL-6) and concomitantly increased concentrations of glucagon (P < 0.05) but not GLP-1.Conclusions: Systemic inflammation caused by bacterial infections or developed as a non-infected condition is associated with increased plasma concentration of glucagon, but not GLP-1. Hyperglucagonemia may contribute to the impaired glucose control in patients with systemic inflammatory diseases.
AB - Objective: Glucagon and glucagon-like peptide-1 (GLP-1) originate from the common precursor, proglucagon, and their plasma concentrations have been reported to be increased during inflammatory conditions. Increased blood glucose levels are frequently observed in septic patients, and therefore we hypothesized that glucagon, but not GLP-1, is increased in individuals with inflammation.Design: Prospective longitudinal cohort study.Materials and methods: We measured glucagon and GLP-1 in plasma sampled consecutively in three cohorts consisting of patients with infective endocarditis (n = 16), urosepsis (n = 28) and post-operative inflammation following percutaneous aortic valve implantation or thoracic endovascular aortic repair (n = 5). Correlations between C-reactive protein (CRP), a marker of systemic inflammation, and glucagon and GLP-1 concentrations were investigated. Additionally, glucagon and GLP-1 concentrations were measured after a bolus infusion of lipopolysaccharide (LPS, 1 ng/kg) in nine healthy young males.Results: Glucagon and CRP were positively and significantly correlated (r = 0.27; P = 0.0003), whereas no significant association between GLP-1 and CRP was found (r = 0.08, P = 0.30). LPS infusion resulted in acute systemic inflammation reflected by increased temperature, pulse, tumor necrosis factor-α (TNFα), interleukin-6 (IL-6) and concomitantly increased concentrations of glucagon (P < 0.05) but not GLP-1.Conclusions: Systemic inflammation caused by bacterial infections or developed as a non-infected condition is associated with increased plasma concentration of glucagon, but not GLP-1. Hyperglucagonemia may contribute to the impaired glucose control in patients with systemic inflammatory diseases.
U2 - 10.1530/EC-20-0590
DO - 10.1530/EC-20-0590
M3 - Journal article
C2 - 33480865
VL - 10
SP - 205
EP - 213
JO - Endocrine Connections
JF - Endocrine Connections
SN - 2049-3614
IS - 2
ER -
ID: 258268115