Plasma CD36 and incident diabetes: A case-cohort study in Danish men and women
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Standard
Plasma CD36 and incident diabetes : A case-cohort study in Danish men and women. / Wang, Yeli; Zhu, Jingwen; Aroner, Sarah; Overvad, Kim; Cai, Tianxi; Yang, Ming; Tjønneland, Anne; Handberg, Aase; Jensen, Majken K.
I: Diabetes and Metabolism Journal, Bind 44, Nr. 1, 2020, s. 134-142.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Plasma CD36 and incident diabetes
T2 - A case-cohort study in Danish men and women
AU - Wang, Yeli
AU - Zhu, Jingwen
AU - Aroner, Sarah
AU - Overvad, Kim
AU - Cai, Tianxi
AU - Yang, Ming
AU - Tjønneland, Anne
AU - Handberg, Aase
AU - Jensen, Majken K.
N1 - Publisher Copyright: Copyright © 2020 Korean Diabetes Association
PY - 2020
Y1 - 2020
N2 - Background: Membrane CD36 is a fatty acid transporter implicated in the pathogenesis of metabolic disease. We aimed to evaluate the association between plasma CD36 levels and diabetes risk and to examine if the association was independent of adiposity among Danish population. Methods: We conducted a case-cohort study nested within the Danish Diet, Cancer and Health study among participants free of cardiovascular disease, diabetes and cancer and with blood samples and anthropometric measurements (height, weight, waist circumference, and body fat percentage) at baseline (1993 to 1997). CD36 levels were measured in 647 incident diabetes cases that occurred before December 2011 and a total of 3,515 case-cohort participants (236 cases overlap). Results: Higher plasma CD36 levels were associated with higher diabetes risk after adjusting for age, sex and other lifestyle factors. The hazard ratio (HR) comparing high versus low tertile of plasma CD36 levels was 1.36 (95% confidence interval [CI], 1.00 to 1.86). However, the association lost its significance after further adjustment for different adiposity indices such as body mass index (HR, 1.23; 95% CI, 0.87 to 1.73), waist circumference (HR, 1.21; 95% CI, 0.88 to 1.68) or body fat percentage (HR, 1.20; 95% CI, 0.86 to 1.66). Moreover, raised plasma CD36 levels were moderately associated with diabetes risk among lean participants, but the association was not present among overweight/obese individuals. Conclusion: Higher plasma CD36 levels were associated with higher diabetes risk, but the association was not independent of adiposity. In this Danish population, the association of CD36 with diabetes risk could be either mediated or confounded by adiposity.
AB - Background: Membrane CD36 is a fatty acid transporter implicated in the pathogenesis of metabolic disease. We aimed to evaluate the association between plasma CD36 levels and diabetes risk and to examine if the association was independent of adiposity among Danish population. Methods: We conducted a case-cohort study nested within the Danish Diet, Cancer and Health study among participants free of cardiovascular disease, diabetes and cancer and with blood samples and anthropometric measurements (height, weight, waist circumference, and body fat percentage) at baseline (1993 to 1997). CD36 levels were measured in 647 incident diabetes cases that occurred before December 2011 and a total of 3,515 case-cohort participants (236 cases overlap). Results: Higher plasma CD36 levels were associated with higher diabetes risk after adjusting for age, sex and other lifestyle factors. The hazard ratio (HR) comparing high versus low tertile of plasma CD36 levels was 1.36 (95% confidence interval [CI], 1.00 to 1.86). However, the association lost its significance after further adjustment for different adiposity indices such as body mass index (HR, 1.23; 95% CI, 0.87 to 1.73), waist circumference (HR, 1.21; 95% CI, 0.88 to 1.68) or body fat percentage (HR, 1.20; 95% CI, 0.86 to 1.66). Moreover, raised plasma CD36 levels were moderately associated with diabetes risk among lean participants, but the association was not present among overweight/obese individuals. Conclusion: Higher plasma CD36 levels were associated with higher diabetes risk, but the association was not independent of adiposity. In this Danish population, the association of CD36 with diabetes risk could be either mediated or confounded by adiposity.
KW - Adiposity
KW - Biomarkers
KW - CD36 antigens
KW - Diabetes mellitus
KW - Epidemiology
KW - Prospective studies
KW - Type 2
U2 - 10.4093/dmj.2018.0273
DO - 10.4093/dmj.2018.0273
M3 - Journal article
C2 - 31701685
AN - SCOPUS:85080892555
VL - 44
SP - 134
EP - 142
JO - Diabetes and Metabolism Journal
JF - Diabetes and Metabolism Journal
SN - 2233-6079
IS - 1
ER -
ID: 286492420