Plant P4-ATPase lipid flippases: How are they regulated?
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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Plant P4-ATPase lipid flippases : How are they regulated? / Villagrana, Richard; López-Marqués, Rosa Laura.
I: Biochimica et Biophysica Acta - Molecular Cell Research, Bind 1871, Nr. 1, 119599, 2024.Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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TY - JOUR
T1 - Plant P4-ATPase lipid flippases
T2 - How are they regulated?
AU - Villagrana, Richard
AU - López-Marqués, Rosa Laura
N1 - Funding Information: Work in the López-Marqués lab is financed by the Novo Nordisk Foundation (Project number NNF19OC0056580/NovoCrops ), the Carlsberg Foundation (project number CF21-0389 ) and the Independent Research Fund Denmark | Nature and Universe (FNU, project number 1026-00024B ). Publisher Copyright: © 2023 The Author(s)
PY - 2024
Y1 - 2024
N2 - P4 ATPases are active membrane transporters that translocate lipids towards the cytosolic side of the biological membranes in eukaryotic cells. Due to their essential cellular functions, P4 ATPase activity is expected to be tightly controlled, but fundamental aspects of the regulation of plant P4 ATPases remain unstudied. In this mini-review, our knowledge of the regulatory mechanisms of yeast and mammalian P4 ATPases will be summarized, and sequence comparison and structural modelling will be used as a basis to discuss the putative regulation of the corresponding plant lipid transporters.
AB - P4 ATPases are active membrane transporters that translocate lipids towards the cytosolic side of the biological membranes in eukaryotic cells. Due to their essential cellular functions, P4 ATPase activity is expected to be tightly controlled, but fundamental aspects of the regulation of plant P4 ATPases remain unstudied. In this mini-review, our knowledge of the regulatory mechanisms of yeast and mammalian P4 ATPases will be summarized, and sequence comparison and structural modelling will be used as a basis to discuss the putative regulation of the corresponding plant lipid transporters.
KW - Autoinhibition
KW - Flippases
KW - Kinase regulation
KW - P4 ATPases
KW - Structural modelling
U2 - 10.1016/j.bbamcr.2023.119599
DO - 10.1016/j.bbamcr.2023.119599
M3 - Review
C2 - 37741575
AN - SCOPUS:85171786421
VL - 1871
JO - B B A - Molecular Cell Research
JF - B B A - Molecular Cell Research
SN - 0167-4889
IS - 1
M1 - 119599
ER -
ID: 391164193