Placebo and nocebo in the treatment of migraine: How much does real world effectiveness depend on contextual effects?
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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Placebo and nocebo in the treatment of migraine : How much does real world effectiveness depend on contextual effects? / Basedau, Hauke; Ornello, Raffaele; Matteis, Eleonora De; Davaasuren, Bolortsetseg; Kadyrova, Begimai; Vuralli, Doga; Bozhenko, Myroslav; Azizova, Ilaha; Bitsadze, Natia; Eralieva, Elnura; Ashina, Messoud; Mitsikostas, Dimos; Puledda, Francesca.
I: Cephalalgia, Bind 43, Nr. 12, 2023, s. 1-12.Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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TY - JOUR
T1 - Placebo and nocebo in the treatment of migraine
T2 - How much does real world effectiveness depend on contextual effects?
AU - Basedau, Hauke
AU - Ornello, Raffaele
AU - Matteis, Eleonora De
AU - Davaasuren, Bolortsetseg
AU - Kadyrova, Begimai
AU - Vuralli, Doga
AU - Bozhenko, Myroslav
AU - Azizova, Ilaha
AU - Bitsadze, Natia
AU - Eralieva, Elnura
AU - Ashina, Messoud
AU - Mitsikostas, Dimos
AU - Puledda, Francesca
N1 - Publisher Copyright: © International Headache Society 2023.
PY - 2023
Y1 - 2023
N2 - Purpose: Treatments in medicine impact individuals beyond their intended effects, due to phenomena such as the placebo and nocebo effects. The placebo effect arises from the positive expectation of a treatment being beneficial, while the nocebo effect stems from the negative expectation of a treatment causing harm. Both in real-world practice and clinical trials, treatments can lead to outcomes unrelated to their intended mechanism of action, which we categorize as placebo and nocebo responses. These responses, combined with the inherent fluctuation in a condition's natural progression, regression to the mean, and random comorbidities, make up a significant part of the therapeutic experience. Particularly in pain management, placebo and nocebo effects play a substantial role. By addressing modifiable contextual factors such as patient expectations, lifestyle choices, and the therapeutic relationship, healthcare providers can enhance the effectiveness of migraine treatments, paving the way for a more comprehensive, individualized approach to patient care. We must also consider non-modifiable factors like personal experiences, beliefs, and information from social media and the internet. Conclusion: This review offers a summary of our current understanding of the placebo and nocebo effects in migraine management.
AB - Purpose: Treatments in medicine impact individuals beyond their intended effects, due to phenomena such as the placebo and nocebo effects. The placebo effect arises from the positive expectation of a treatment being beneficial, while the nocebo effect stems from the negative expectation of a treatment causing harm. Both in real-world practice and clinical trials, treatments can lead to outcomes unrelated to their intended mechanism of action, which we categorize as placebo and nocebo responses. These responses, combined with the inherent fluctuation in a condition's natural progression, regression to the mean, and random comorbidities, make up a significant part of the therapeutic experience. Particularly in pain management, placebo and nocebo effects play a substantial role. By addressing modifiable contextual factors such as patient expectations, lifestyle choices, and the therapeutic relationship, healthcare providers can enhance the effectiveness of migraine treatments, paving the way for a more comprehensive, individualized approach to patient care. We must also consider non-modifiable factors like personal experiences, beliefs, and information from social media and the internet. Conclusion: This review offers a summary of our current understanding of the placebo and nocebo effects in migraine management.
KW - contextual effects
KW - headache
KW - Migraine
KW - nocebo
KW - placebo
U2 - 10.1177/03331024231218392
DO - 10.1177/03331024231218392
M3 - Review
C2 - 38041833
AN - SCOPUS:85178349258
VL - 43
SP - 1
EP - 12
JO - Cephalalgia
JF - Cephalalgia
SN - 0800-1952
IS - 12
ER -
ID: 389904867