Physician-defined severe toxicities occurring during and after cancer treatment: Modified consensus definitions and clinical applicability in the evaluation of cancer treatment
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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Physician-defined severe toxicities occurring during and after cancer treatment : Modified consensus definitions and clinical applicability in the evaluation of cancer treatment. / Nielsen, Camilla Grud; Thomsen, Birthe Lykke; Als-Nielsen, Bodil; Conyers, Rachel; Jeha, Sima; Mateos, Marion K.; Mlynarski, Wojciech; Pieters, Rob; Rathe, Mathias; Schmiegelow, Kjeld; Andres-Jensen, Liv; Ponte Legno Severe Toxicity.
I: Frontiers in Pediatrics, Bind 11, 1155449, 2023.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Physician-defined severe toxicities occurring during and after cancer treatment
T2 - Modified consensus definitions and clinical applicability in the evaluation of cancer treatment
AU - Nielsen, Camilla Grud
AU - Thomsen, Birthe Lykke
AU - Als-Nielsen, Bodil
AU - Conyers, Rachel
AU - Jeha, Sima
AU - Mateos, Marion K.
AU - Mlynarski, Wojciech
AU - Pieters, Rob
AU - Rathe, Mathias
AU - Schmiegelow, Kjeld
AU - Andres-Jensen, Liv
AU - Ponte Legno Severe Toxicity
PY - 2023
Y1 - 2023
N2 - Overall survival after cancer is increasing for the majority of cancer types, but survivors can be burdened lifelong by treatment-related severe toxicities. Integration of long-term toxicities in treatment evaluation is not least important for children and young adults with cancers with high survival probability. We present modified consensus definitions of 21 previously published physician-defined Severe Toxicities (STs), each reflecting the most serious long-term treatment-related toxicities and representing an unacceptable price for cure. Applying the Severe Toxicity (ST) concept to real-world data required careful adjustments of the original consensus definitions, translating them into standardized endpoints for evaluating treatment-related outcomes to ensure that (1) the STs can be classified uniformly and prospectively across different cohorts, and (2) the ST definitions allow for valid statistical analyses. The current paper presents the resulting modified consensus definitions of the 21 STs proposed to be included in outcome reporting of cancer treatment.
AB - Overall survival after cancer is increasing for the majority of cancer types, but survivors can be burdened lifelong by treatment-related severe toxicities. Integration of long-term toxicities in treatment evaluation is not least important for children and young adults with cancers with high survival probability. We present modified consensus definitions of 21 previously published physician-defined Severe Toxicities (STs), each reflecting the most serious long-term treatment-related toxicities and representing an unacceptable price for cure. Applying the Severe Toxicity (ST) concept to real-world data required careful adjustments of the original consensus definitions, translating them into standardized endpoints for evaluating treatment-related outcomes to ensure that (1) the STs can be classified uniformly and prospectively across different cohorts, and (2) the ST definitions allow for valid statistical analyses. The current paper presents the resulting modified consensus definitions of the 21 STs proposed to be included in outcome reporting of cancer treatment.
KW - cancer treatment
KW - toxicities
KW - childhood cancer
KW - long-term
KW - severe-toxicity-free-survival
KW - COMPETING RISKS
KW - CHILDHOOD
KW - BURDEN
U2 - 10.3389/fped.2023.1155449
DO - 10.3389/fped.2023.1155449
M3 - Journal article
C2 - 37181427
VL - 11
JO - Frontiers in Pediatrics
JF - Frontiers in Pediatrics
SN - 2296-2360
M1 - 1155449
ER -
ID: 347864893