TY - JOUR

T1 - Physical activity attenuates but does not eliminate coronary heart disease risk amongst adults with risk factors

T2 - EPIC-CVD case-cohort study

AU - Fortuin-de Smidt, Melony C

AU - Sewe, Maquins Odhiambo

AU - Lassale, Camille

AU - Weiderpass, Elisabete

AU - Andersson, Jonas

AU - Huerta, José María

AU - Ekelund, Ulf

AU - Aleksandrova, Krasimira

AU - Tong, Tammy Yn

AU - Dahm, Christina C

AU - Tjønneland, Anne

AU - Kyrø, Cecilie

AU - Steindorf, Karen

AU - Schulze, Matthias B

AU - Katzke, Verena

AU - Sacerdote, Carlotta

AU - Agnoli, Claudia

AU - Masala, Giovanna

AU - Tumino, Rosario

AU - Panico, Salvatore

AU - Boer, Jolanda Ma

AU - Onland-Moret, N Charlotte

AU - Wendel-Vos, Gc Wanda

AU - van der Schouw, Yvonne T

AU - Borch, Kristin Benjaminsen

AU - Agudo, Antonio

AU - Petrova, Dafina

AU - Chirlaque, María-Dolores

AU - Conchi, Moreno-Iribas

AU - Amiano, Pilar

AU - Melander, Olle

AU - Heath, Alicia K

AU - Aune, Dagfinn

AU - Forouhi, Nita G

AU - Langenberg, Claudia

AU - Brage, Soren

AU - Riboli, Elio

AU - Wareham, Nicholas J

AU - Danesh, John

AU - Butterworth, Adam S

AU - Wennberg, Patrik

N1 - © The Author(s) 2022. Published by Oxford University Press on behalf of European Society of Cardiology.

PY - 2022

Y1 - 2022

N2 - AIMS: This study aimed to evaluate the association between physical activity and the incidence of coronary heart disease (CHD) in individuals with and without CHD risk factors.METHODS AND RESULTS: EPIC-CVD is a case-cohort study of 29 333 participants that included 13 582 incident CHD cases and a randomly selected sub-cohort nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Self-reported physical activity was summarized using the Cambridge physical activity index (inactive, moderately inactive, moderately active, and active). Participants were categorized into sub-groups based on the presence or the absence of the following risk factors: obesity (body mass index ≥30 kg/m2), hypercholesterolaemia (total cholesterol ≥6.2 mmol/L), history of diabetes, hypertension (self-reported or ≥140/90 mmHg), and current smoking. Prentice-weighted Cox regression was used to assess the association between physical activity and incident CHD events (non-fatal and fatal).Compared to inactive participants without the respective CHD risk factor (referent), excess CHD risk was highest in physically inactive and lowest in moderately active participants with CHD risk factors. Corresponding excess CHD risk estimates amongst those with obesity were 47% [95% confidence interval (CI) 32-64%] and 21% (95%CI 2-44%), with hypercholesterolaemia were 80% (95%CI 55-108%) and 48% (95%CI 22-81%), with hypertension were 80% (95%CI 65-96%) and 49% (95%CI 28-74%), with diabetes were 142% (95%CI 63-260%), and 100% (95%CI 32-204%), and amongst smokers were 152% (95%CI 122-186%) and 109% (95%CI 74-150%).CONCLUSIONS: In people with CHD risk factors, moderate physical activity, equivalent to 40 mins of walking per day, attenuates but does not completely offset CHD risk.

AB - AIMS: This study aimed to evaluate the association between physical activity and the incidence of coronary heart disease (CHD) in individuals with and without CHD risk factors.METHODS AND RESULTS: EPIC-CVD is a case-cohort study of 29 333 participants that included 13 582 incident CHD cases and a randomly selected sub-cohort nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Self-reported physical activity was summarized using the Cambridge physical activity index (inactive, moderately inactive, moderately active, and active). Participants were categorized into sub-groups based on the presence or the absence of the following risk factors: obesity (body mass index ≥30 kg/m2), hypercholesterolaemia (total cholesterol ≥6.2 mmol/L), history of diabetes, hypertension (self-reported or ≥140/90 mmHg), and current smoking. Prentice-weighted Cox regression was used to assess the association between physical activity and incident CHD events (non-fatal and fatal).Compared to inactive participants without the respective CHD risk factor (referent), excess CHD risk was highest in physically inactive and lowest in moderately active participants with CHD risk factors. Corresponding excess CHD risk estimates amongst those with obesity were 47% [95% confidence interval (CI) 32-64%] and 21% (95%CI 2-44%), with hypercholesterolaemia were 80% (95%CI 55-108%) and 48% (95%CI 22-81%), with hypertension were 80% (95%CI 65-96%) and 49% (95%CI 28-74%), with diabetes were 142% (95%CI 63-260%), and 100% (95%CI 32-204%), and amongst smokers were 152% (95%CI 122-186%) and 109% (95%CI 74-150%).CONCLUSIONS: In people with CHD risk factors, moderate physical activity, equivalent to 40 mins of walking per day, attenuates but does not completely offset CHD risk.

U2 - 10.1093/eurjpc/zwac055

DO - 10.1093/eurjpc/zwac055

M3 - Journal article

C2 - 35403197

VL - 29

SP - 1618

EP - 1629

JO - European Journal of Preventive Cardiology

JF - European Journal of Preventive Cardiology

SN - 2047-4873

IS - 11

ER -