Phenotypic Convergence Is Not Mirrored at the Protein Level in a Lizard Adaptive Radiation
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Phenotypic Convergence Is Not Mirrored at the Protein Level in a Lizard Adaptive Radiation. / Corbett-Detig, Russell B.; Russell, Shelbi L.; Nielsen, Rasmus; Losos, Jonathan.
I: MOLECULAR BIOLOGY AND EVOLUTION , Bind 37, Nr. 6, 2020, s. 1604-1614.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Phenotypic Convergence Is Not Mirrored at the Protein Level in a Lizard Adaptive Radiation
AU - Corbett-Detig, Russell B.
AU - Russell, Shelbi L.
AU - Nielsen, Rasmus
AU - Losos, Jonathan
PY - 2020
Y1 - 2020
N2 - There are many compelling examples of molecular convergence at individual genes. However, the prevalence and the relative importance of adaptive genome-wide convergence remain largely unknown. Many recent works have reported striking examples of excess genome-wide convergence, but some of these studies have been called into question because of the use of inappropriate null models. Here, we sequenced and compared the genomes of 12 species of anole lizards that have independently converged on suites of adaptive behavioral and morphological traits. Despite extensive searches for a genome-wide signature of molecular convergence, we found no evidence supporting molecular convergence at specific amino acids either at individual genes or at genome-wide comparisons; we also uncovered no evidence supporting an excess of adaptive convergence in the rates of amino acid substitutions within genes. Our findings indicate that comprehensive phenotypic convergence is not mirrored at genome-wide protein-coding levels in anoles, and therefore, that adaptive phenotypic convergence is likely not constrained by the evolution of many specific protein sequences or structures.
AB - There are many compelling examples of molecular convergence at individual genes. However, the prevalence and the relative importance of adaptive genome-wide convergence remain largely unknown. Many recent works have reported striking examples of excess genome-wide convergence, but some of these studies have been called into question because of the use of inappropriate null models. Here, we sequenced and compared the genomes of 12 species of anole lizards that have independently converged on suites of adaptive behavioral and morphological traits. Despite extensive searches for a genome-wide signature of molecular convergence, we found no evidence supporting molecular convergence at specific amino acids either at individual genes or at genome-wide comparisons; we also uncovered no evidence supporting an excess of adaptive convergence in the rates of amino acid substitutions within genes. Our findings indicate that comprehensive phenotypic convergence is not mirrored at genome-wide protein-coding levels in anoles, and therefore, that adaptive phenotypic convergence is likely not constrained by the evolution of many specific protein sequences or structures.
KW - molecular evolution
KW - convergence
KW - Anolis
KW - MOLECULAR CONVERGENCE
KW - PHYLOGENETIC ANALYSIS
KW - EVOLUTION
KW - GENOME
KW - CONCORDANCE
KW - HOMOPLASY
KW - MAFFT
KW - TOOL
U2 - 10.1093/molbev/msaa028
DO - 10.1093/molbev/msaa028
M3 - Journal article
C2 - 32027369
VL - 37
SP - 1604
EP - 1614
JO - Molecular Biology and Evolution
JF - Molecular Biology and Evolution
SN - 0737-4038
IS - 6
ER -
ID: 250549758