PET med amyloidligander bør ikke anvendesrutinemæssigt i tidlig diagnostik af Alzheimerssygdom – en gennemgang af et Cochranereview
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PET med amyloidligander bør ikke anvendesrutinemæssigt i tidlig diagnostik af Alzheimerssygdom – en gennemgang af et Cochranereview. / Hasselbalch, Steen Gregers.
I: Ugeskrift for Laeger, Bind 177, Nr. 32, 03.08.2015, s. V11140610.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - PET med amyloidligander bør ikke anvendesrutinemæssigt i tidlig diagnostik af Alzheimerssygdom – en gennemgang af et Cochranereview
AU - Hasselbalch, Steen Gregers
PY - 2015/8/3
Y1 - 2015/8/3
N2 - Recent diagnostic criteria for Alzheimer's disease incorporate biomarkers in order to increase the diagnostic accuracy. In a recent Cochrane review the ligand (11)C-PiB showed a high sensitivity, but low specificity for detecting patients with mild cognitive impairment who would develop Alzheimer's dementia. Given the evolution of Alzheimer pathology, these findings are not surprising. With current limited treatment options for MCI, (11)C-PiB-PET cannot be recommended for routine use in MCI and should be used only in selected cases where a positive scan will alter management.
AB - Recent diagnostic criteria for Alzheimer's disease incorporate biomarkers in order to increase the diagnostic accuracy. In a recent Cochrane review the ligand (11)C-PiB showed a high sensitivity, but low specificity for detecting patients with mild cognitive impairment who would develop Alzheimer's dementia. Given the evolution of Alzheimer pathology, these findings are not surprising. With current limited treatment options for MCI, (11)C-PiB-PET cannot be recommended for routine use in MCI and should be used only in selected cases where a positive scan will alter management.
M3 - Tidsskriftartikel
C2 - 26321582
VL - 177
SP - V11140610
JO - Ugeskrift for Laeger
JF - Ugeskrift for Laeger
SN - 0041-5782
IS - 32
ER -
ID: 162416555