Peripheral Endothelial Function and Coronary Flow Velocity Reserve Are Not Associated in Women with Angina and No Obstructive Coronary Artery Disease: The iPOWER Study
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Peripheral Endothelial Function and Coronary Flow Velocity Reserve Are Not Associated in Women with Angina and No Obstructive Coronary Artery Disease : The iPOWER Study. / Flintholm Raft, Kristoffer; Frestad, Daria; Michelsen, Marie Mide; Suhrs, Hannah Elena; Rask, Anna Bay; Nilsson, Malin; Hermann, Thomas Steffen; Prescott, Eva.
I: Journal of Vascular Research, Bind 54, Nr. 5, 2017, s. 309-319.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Peripheral Endothelial Function and Coronary Flow Velocity Reserve Are Not Associated in Women with Angina and No Obstructive Coronary Artery Disease
T2 - The iPOWER Study
AU - Flintholm Raft, Kristoffer
AU - Frestad, Daria
AU - Michelsen, Marie Mide
AU - Suhrs, Hannah Elena
AU - Rask, Anna Bay
AU - Nilsson, Malin
AU - Hermann, Thomas Steffen
AU - Prescott, Eva
N1 - © 2017 S. Karger AG, Basel.
PY - 2017
Y1 - 2017
N2 - PURPOSE: We investigated whether impaired flow-mediated dilation (FMD) and plasma biomarkers reflecting endothelial dysfunction are associated with coronary microvascular dysfunction (CMD) in women with angina and no obstructive coronary artery disease (CAD).METHODS: Patients (n = 194) were randomly selected women with angina pectoris and no obstructive CAD (<50% stenosis). A reference population of asymptomatic women without CAD (n = 25) was included. We measured FMD in the brachial artery by high-resolution ultrasound. Coronary flow velocity reserve (CFVR) was assessed by transthoracic Doppler flow echocardiography (TTDE) of the left anterior descending artery during rest and high-dose dipyridamole infusion. CMD was defined as CFVR <2.RESULTS: FMD and CFVR were measured in 128 patients and 21 controls. Mean (SD) age was 64.5 (8.9) years, mean CFVR was 2.3 (2.0-2.7), and mean FMD was 8.4% (4.8%) in angina patients. Angina patients had a higher risk factor burden compared with the reference population. Measures of peripheral endothelial dysfunction and endothelial plasma biomarkers did not differ according to angina or CFVR. CFVR and FMD did not correlate (Spearman ρ = -0.07, p = 0.45).CONCLUSIONS: FMD and biomarkers of endothelial dysfunction did not identify individuals with CMD assessed as impaired CFVR by TTDE in women with angina and no obstructive CAD.
AB - PURPOSE: We investigated whether impaired flow-mediated dilation (FMD) and plasma biomarkers reflecting endothelial dysfunction are associated with coronary microvascular dysfunction (CMD) in women with angina and no obstructive coronary artery disease (CAD).METHODS: Patients (n = 194) were randomly selected women with angina pectoris and no obstructive CAD (<50% stenosis). A reference population of asymptomatic women without CAD (n = 25) was included. We measured FMD in the brachial artery by high-resolution ultrasound. Coronary flow velocity reserve (CFVR) was assessed by transthoracic Doppler flow echocardiography (TTDE) of the left anterior descending artery during rest and high-dose dipyridamole infusion. CMD was defined as CFVR <2.RESULTS: FMD and CFVR were measured in 128 patients and 21 controls. Mean (SD) age was 64.5 (8.9) years, mean CFVR was 2.3 (2.0-2.7), and mean FMD was 8.4% (4.8%) in angina patients. Angina patients had a higher risk factor burden compared with the reference population. Measures of peripheral endothelial dysfunction and endothelial plasma biomarkers did not differ according to angina or CFVR. CFVR and FMD did not correlate (Spearman ρ = -0.07, p = 0.45).CONCLUSIONS: FMD and biomarkers of endothelial dysfunction did not identify individuals with CMD assessed as impaired CFVR by TTDE in women with angina and no obstructive CAD.
KW - Aged
KW - Angina Pectoris/diagnosis
KW - Blood Flow Velocity
KW - Brachial Artery/diagnostic imaging
KW - Coronary Stenosis/complications
KW - Coronary Vessels/physiopathology
KW - Dipyridamole/administration & dosage
KW - Echocardiography, Doppler
KW - Endothelium, Vascular/physiopathology
KW - Female
KW - Fractional Flow Reserve, Myocardial
KW - Humans
KW - Microcirculation
KW - Middle Aged
KW - Predictive Value of Tests
KW - Regional Blood Flow
KW - Risk Factors
KW - Severity of Illness Index
KW - Vasodilation
KW - Vasodilator Agents/administration & dosage
U2 - 10.1159/000479374
DO - 10.1159/000479374
M3 - Journal article
C2 - 28942444
VL - 54
SP - 309
EP - 319
JO - Journal of Vascular Research
JF - Journal of Vascular Research
SN - 1018-1172
IS - 5
ER -
ID: 194976732