Perioperative Rehabilitation in Operable Lung Cancer Patients (PROLUCA): A Feasibility Study
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Perioperative Rehabilitation in Operable Lung Cancer Patients (PROLUCA) : A Feasibility Study. / Sommer, Maja S; Trier, Karen; Vibe-Petersen, Jette; Missel, Malene; Christensen, Merete; Larsen, Klaus R.; Langer, Seppo W.; Hendriksen, Carsten; Clementsen, Paul Frost; H. Pedersen, Jesper; Langberg, Henning.
I: Integrative Cancer Therapies, Bind 15, Nr. 4, 2016, s. 455-466.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Perioperative Rehabilitation in Operable Lung Cancer Patients (PROLUCA)
T2 - A Feasibility Study
AU - Sommer, Maja S
AU - Trier, Karen
AU - Vibe-Petersen, Jette
AU - Missel, Malene
AU - Christensen, Merete
AU - Larsen, Klaus R.
AU - Langer, Seppo W.
AU - Hendriksen, Carsten
AU - Clementsen, Paul Frost
AU - H. Pedersen, Jesper
AU - Langberg, Henning
N1 - © The Author(s) 2016.
PY - 2016
Y1 - 2016
N2 - Introduction: Surgical resection in patients with non-small cell lung cancer (NSCLC) may be associated with significant morbidity, functional limitations, and decreased quality of life. Objectives: The safety and feasibility of a preoperative and early postoperative rehabilitation program in patients operated for NSCLC was determined in a nonhospital setting, with focus on high-intensity interval exercise. Methods: Forty patients with biopsy-proven NSCLC stages I to IIIa referred for surgical resection at the Department of Cardiothoracic Surgery RT, Rigshospitalet, University of Copenhagen, were randomly assigned to 1 of 4 groups (3 intervention groups and 1 control group). The preoperative intervention consisted of a home-based exercise program, while the postoperative exercise program comprised a supervised group exercise program involving resistance and high-intensity interval cardiorespiratory exercise 2 hours weekly for 12 weeks combined with individual counseling. The study endpoints were inclusion rate, adherence, and number of adverse events. Results: Forty patients (of 124 screened; 32%) were included and randomized into the 4 groups. The postoperative exercise was completed by 73% of the patients randomized to this intervention. No adverse events were observed, indicating that the early postoperative exercise program is safe. The preoperative home-based exercise program was not feasible due to interfering diagnostic procedures and fast-track surgery that left only 1 to 2 weeks between diagnosis and surgery.Conclusion: The early postoperative exercise program for patients with NSCLC was safe and feasible, but in a fast-track set up, a preoperative home-based exercise program was not feasible for this population.
AB - Introduction: Surgical resection in patients with non-small cell lung cancer (NSCLC) may be associated with significant morbidity, functional limitations, and decreased quality of life. Objectives: The safety and feasibility of a preoperative and early postoperative rehabilitation program in patients operated for NSCLC was determined in a nonhospital setting, with focus on high-intensity interval exercise. Methods: Forty patients with biopsy-proven NSCLC stages I to IIIa referred for surgical resection at the Department of Cardiothoracic Surgery RT, Rigshospitalet, University of Copenhagen, were randomly assigned to 1 of 4 groups (3 intervention groups and 1 control group). The preoperative intervention consisted of a home-based exercise program, while the postoperative exercise program comprised a supervised group exercise program involving resistance and high-intensity interval cardiorespiratory exercise 2 hours weekly for 12 weeks combined with individual counseling. The study endpoints were inclusion rate, adherence, and number of adverse events. Results: Forty patients (of 124 screened; 32%) were included and randomized into the 4 groups. The postoperative exercise was completed by 73% of the patients randomized to this intervention. No adverse events were observed, indicating that the early postoperative exercise program is safe. The preoperative home-based exercise program was not feasible due to interfering diagnostic procedures and fast-track surgery that left only 1 to 2 weeks between diagnosis and surgery.Conclusion: The early postoperative exercise program for patients with NSCLC was safe and feasible, but in a fast-track set up, a preoperative home-based exercise program was not feasible for this population.
U2 - 10.1177/1534735416635741
DO - 10.1177/1534735416635741
M3 - Journal article
C2 - 27151595
VL - 15
SP - 455
EP - 466
JO - Integrative Cancer Therapies
JF - Integrative Cancer Therapies
SN - 1534-7354
IS - 4
ER -
ID: 165792999