Perinatal origin of testicular germ cell cancer: Possible involvement of developmental reprogramming

Publikation: Bidrag til bog/antologi/rapport › Bidrag til bog/antologi › Forskning › fagfællebedømt

Standard

Perinatal origin of testicular germ cell cancer : Possible involvement of developmental reprogramming. / Almstrup, Kristian; Meyts, Ewa Rajpert De; Skakkebæk, Niels E.

Perinatal Programming: The State of the Art. Walter de Gruyter GmbH and Co. KG, 2011. s. 219-228.

Publikation: Bidrag til bog/antologi/rapport › Bidrag til bog/antologi › Forskning › fagfællebedømt

Harvard

Almstrup, K, Meyts, ERD & Skakkebæk, NE 2011, Perinatal origin of testicular germ cell cancer: Possible involvement of developmental reprogramming. i Perinatal Programming: The State of the Art. Walter de Gruyter GmbH and Co. KG, s. 219-228. https://doi.org/10.1515/9783110249453

APA

Almstrup, K., Meyts, E. R. D., & Skakkebæk, N. E. (2011). Perinatal origin of testicular germ cell cancer: Possible involvement of developmental reprogramming. I Perinatal Programming: The State of the Art (s. 219-228). Walter de Gruyter GmbH and Co. KG. https://doi.org/10.1515/9783110249453

Vancouver

Almstrup K, Meyts ERD, Skakkebæk NE. Perinatal origin of testicular germ cell cancer: Possible involvement of developmental reprogramming. I Perinatal Programming: The State of the Art. Walter de Gruyter GmbH and Co. KG. 2011. s. 219-228 https://doi.org/10.1515/9783110249453

Author

Almstrup, Kristian ; Meyts, Ewa Rajpert De ; Skakkebæk, Niels E. / Perinatal origin of testicular germ cell cancer : Possible involvement of developmental reprogramming. Perinatal Programming: The State of the Art. Walter de Gruyter GmbH and Co. KG, 2011. s. 219-228

Bibtex

@inbook{7806e39b8baa4c98a279b37763339edb,
title = "Perinatal origin of testicular germ cell cancer: Possible involvement of developmental reprogramming",
abstract = "Testicular dysgenesis syndrome is manifested as poor semen quality, undescended testes, hypospadias, or testicular germ cell cancer. The current hypothesis on the pathogenic events leading to testicular dysgenesis involves improper development of somatic nurse cells and consequently delayed germ cell development. Most evidence comes from testicular germ cell cancer, which is the most common cancer in young men. It develops through a preinvasive carcinoma in situ (CIS) stage. Much data indicate that the CIS cell is a neoplastic and pluripotent counterpart of a primordial germ cell (PGC) or gonocyte that has failed to differentiate. During their development both PGC and gonocytes undergo extensive epigenetic modifi cations, including erasure and reestablishment of genome wide DNA methylation and exchange of histone modifi cations. This chapter reviews the current knowledge on the perinatal reprogramming of fetal germ cells and its possible involvement in testicular cancer pathogenesis.",
author = "Kristian Almstrup and Meyts, {Ewa Rajpert De} and Skakkeb{\ae}k, {Niels E.}",
year = "2011",
month = nov,
day = "30",
doi = "10.1515/9783110249453",
language = "English",
isbn = "9783110249446",
pages = "219--228",
booktitle = "Perinatal Programming",
publisher = "Walter de Gruyter GmbH and Co. KG",

}

RIS

TY - CHAP

T1 - Perinatal origin of testicular germ cell cancer

T2 - Possible involvement of developmental reprogramming

AU - Almstrup, Kristian

AU - Meyts, Ewa Rajpert De

AU - Skakkebæk, Niels E.

PY - 2011/11/30

Y1 - 2011/11/30

N2 - Testicular dysgenesis syndrome is manifested as poor semen quality, undescended testes, hypospadias, or testicular germ cell cancer. The current hypothesis on the pathogenic events leading to testicular dysgenesis involves improper development of somatic nurse cells and consequently delayed germ cell development. Most evidence comes from testicular germ cell cancer, which is the most common cancer in young men. It develops through a preinvasive carcinoma in situ (CIS) stage. Much data indicate that the CIS cell is a neoplastic and pluripotent counterpart of a primordial germ cell (PGC) or gonocyte that has failed to differentiate. During their development both PGC and gonocytes undergo extensive epigenetic modifi cations, including erasure and reestablishment of genome wide DNA methylation and exchange of histone modifi cations. This chapter reviews the current knowledge on the perinatal reprogramming of fetal germ cells and its possible involvement in testicular cancer pathogenesis.

AB - Testicular dysgenesis syndrome is manifested as poor semen quality, undescended testes, hypospadias, or testicular germ cell cancer. The current hypothesis on the pathogenic events leading to testicular dysgenesis involves improper development of somatic nurse cells and consequently delayed germ cell development. Most evidence comes from testicular germ cell cancer, which is the most common cancer in young men. It develops through a preinvasive carcinoma in situ (CIS) stage. Much data indicate that the CIS cell is a neoplastic and pluripotent counterpart of a primordial germ cell (PGC) or gonocyte that has failed to differentiate. During their development both PGC and gonocytes undergo extensive epigenetic modifi cations, including erasure and reestablishment of genome wide DNA methylation and exchange of histone modifi cations. This chapter reviews the current knowledge on the perinatal reprogramming of fetal germ cells and its possible involvement in testicular cancer pathogenesis.

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U2 - 10.1515/9783110249453

DO - 10.1515/9783110249453

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SP - 219

EP - 228

BT - Perinatal Programming

PB - Walter de Gruyter GmbH and Co. KG

ER -

ID: 284205699