Pericardial Adipose Tissue Volume Is Independently Associated With Human Immunodeficiency Virus Status and Prior Use of Stavudine, Didanosine, or Indinavir

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Standard

Pericardial Adipose Tissue Volume Is Independently Associated With Human Immunodeficiency Virus Status and Prior Use of Stavudine, Didanosine, or Indinavir. / Knudsen, Andreas D; Krebs-Demmer, Lisanne; Bjørge, Natascha I D; Elming, Marie B; Gelpi, Marco; Sigvardsen, Per E; Lebech, Anne-Mette; Fuchs, Andreas; Kühl, Jørgen T; Køber, Lars; Lundgren, Jens; Nordestgaard, Børge G; Kofoed, Klaus F; Nielsen, Susanne D.

I: The Journal of Infectious Diseases, Bind 222, Nr. 1, 2020, s. 54-61.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Knudsen, AD, Krebs-Demmer, L, Bjørge, NID, Elming, MB, Gelpi, M, Sigvardsen, PE, Lebech, A-M, Fuchs, A, Kühl, JT, Køber, L, Lundgren, J, Nordestgaard, BG, Kofoed, KF & Nielsen, SD 2020, 'Pericardial Adipose Tissue Volume Is Independently Associated With Human Immunodeficiency Virus Status and Prior Use of Stavudine, Didanosine, or Indinavir', The Journal of Infectious Diseases, bind 222, nr. 1, s. 54-61. https://doi.org/10.1093/infdis/jiaa057

APA

Knudsen, A. D., Krebs-Demmer, L., Bjørge, N. I. D., Elming, M. B., Gelpi, M., Sigvardsen, P. E., Lebech, A-M., Fuchs, A., Kühl, J. T., Køber, L., Lundgren, J., Nordestgaard, B. G., Kofoed, K. F., & Nielsen, S. D. (2020). Pericardial Adipose Tissue Volume Is Independently Associated With Human Immunodeficiency Virus Status and Prior Use of Stavudine, Didanosine, or Indinavir. The Journal of Infectious Diseases, 222(1), 54-61. https://doi.org/10.1093/infdis/jiaa057

Vancouver

Knudsen AD, Krebs-Demmer L, Bjørge NID, Elming MB, Gelpi M, Sigvardsen PE o.a. Pericardial Adipose Tissue Volume Is Independently Associated With Human Immunodeficiency Virus Status and Prior Use of Stavudine, Didanosine, or Indinavir. The Journal of Infectious Diseases. 2020;222(1):54-61. https://doi.org/10.1093/infdis/jiaa057

Author

Knudsen, Andreas D ; Krebs-Demmer, Lisanne ; Bjørge, Natascha I D ; Elming, Marie B ; Gelpi, Marco ; Sigvardsen, Per E ; Lebech, Anne-Mette ; Fuchs, Andreas ; Kühl, Jørgen T ; Køber, Lars ; Lundgren, Jens ; Nordestgaard, Børge G ; Kofoed, Klaus F ; Nielsen, Susanne D. / Pericardial Adipose Tissue Volume Is Independently Associated With Human Immunodeficiency Virus Status and Prior Use of Stavudine, Didanosine, or Indinavir. I: The Journal of Infectious Diseases. 2020 ; Bind 222, Nr. 1. s. 54-61.

Bibtex

@article{149c9380c41f443f9e8dda392c27bdba,
title = "Pericardial Adipose Tissue Volume Is Independently Associated With Human Immunodeficiency Virus Status and Prior Use of Stavudine, Didanosine, or Indinavir",
abstract = "BACKGROUND: Increased pericardial adipose tissue is associated with higher risk of cardiovascular disease. We aimed to determine whether human immunodeficiency virus (HIV) status was independently associated with larger pericardial adipose tissue volume and to explore possible HIV-specific risk factors.METHODS: Persons with HIV (PWH) were recruited from the Copenhagen Comorbidity in HIV Infection (COCOMO) Study and matched 1:1 on age and sex to uninfected controls. Pericardial adipose tissue volume was measured using cardiac computed tomography.RESULTS: A total of 587 PWH and 587 controls were included. Median age was 52 years, and 88% were male. Human immunodeficiency virus status was independently associated with 17 mL (95% confidence interval [CI], 10-23; P < .001) larger pericardial adipose tissue volume. Larger pericardial adipose tissue volume was associated with low CD4+ nadir and prior use of stavudine, didanosine, and indinavir. Among PWH without thymidine analogue or didanosine exposure, time since initiating combination antiretroviral treatment (per 5-year use) was associated with l6 mL (95% CI, -6 to -25; P = .002) lower pericardial adipose tissue volume.CONCLUSIONS: Human immunodeficiency virus status was independently associated with larger pericardial adipose tissue volume. Severe immunodeficiency, stavudine, didanosine, and indinavir were associated with larger pericardial adipose tissue volume. Persons with HIV with prior exposure to these drugs may constitute a distinct cardiovascular risk population.",
keywords = "Adipose Tissue/drug effects, Adult, Anti-HIV Agents/adverse effects, Cardiovascular Diseases/chemically induced, Denmark, Didanosine/adverse effects, Female, HIV Infections/drug therapy, HIV Protease Inhibitors/therapeutic use, Healthy Volunteers, Humans, Indinavir/adverse effects, Male, Middle Aged, Pericardium/physiopathology, Risk Factors, Stavudine/adverse effects, Viral Load",
author = "Knudsen, {Andreas D} and Lisanne Krebs-Demmer and Bj{\o}rge, {Natascha I D} and Elming, {Marie B} and Marco Gelpi and Sigvardsen, {Per E} and Anne-Mette Lebech and Andreas Fuchs and K{\"u}hl, {J{\o}rgen T} and Lars K{\o}ber and Jens Lundgren and Nordestgaard, {B{\o}rge G} and Kofoed, {Klaus F} and Nielsen, {Susanne D}",
note = "{\textcopyright} The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.",
year = "2020",
doi = "10.1093/infdis/jiaa057",
language = "English",
volume = "222",
pages = "54--61",
journal = "Journal of Infectious Diseases",
issn = "0022-1899",
publisher = "Oxford University Press",
number = "1",

}

RIS

TY - JOUR

T1 - Pericardial Adipose Tissue Volume Is Independently Associated With Human Immunodeficiency Virus Status and Prior Use of Stavudine, Didanosine, or Indinavir

AU - Knudsen, Andreas D

AU - Krebs-Demmer, Lisanne

AU - Bjørge, Natascha I D

AU - Elming, Marie B

AU - Gelpi, Marco

AU - Sigvardsen, Per E

AU - Lebech, Anne-Mette

AU - Fuchs, Andreas

AU - Kühl, Jørgen T

AU - Køber, Lars

AU - Lundgren, Jens

AU - Nordestgaard, Børge G

AU - Kofoed, Klaus F

AU - Nielsen, Susanne D

N1 - © The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.

PY - 2020

Y1 - 2020

N2 - BACKGROUND: Increased pericardial adipose tissue is associated with higher risk of cardiovascular disease. We aimed to determine whether human immunodeficiency virus (HIV) status was independently associated with larger pericardial adipose tissue volume and to explore possible HIV-specific risk factors.METHODS: Persons with HIV (PWH) were recruited from the Copenhagen Comorbidity in HIV Infection (COCOMO) Study and matched 1:1 on age and sex to uninfected controls. Pericardial adipose tissue volume was measured using cardiac computed tomography.RESULTS: A total of 587 PWH and 587 controls were included. Median age was 52 years, and 88% were male. Human immunodeficiency virus status was independently associated with 17 mL (95% confidence interval [CI], 10-23; P < .001) larger pericardial adipose tissue volume. Larger pericardial adipose tissue volume was associated with low CD4+ nadir and prior use of stavudine, didanosine, and indinavir. Among PWH without thymidine analogue or didanosine exposure, time since initiating combination antiretroviral treatment (per 5-year use) was associated with l6 mL (95% CI, -6 to -25; P = .002) lower pericardial adipose tissue volume.CONCLUSIONS: Human immunodeficiency virus status was independently associated with larger pericardial adipose tissue volume. Severe immunodeficiency, stavudine, didanosine, and indinavir were associated with larger pericardial adipose tissue volume. Persons with HIV with prior exposure to these drugs may constitute a distinct cardiovascular risk population.

AB - BACKGROUND: Increased pericardial adipose tissue is associated with higher risk of cardiovascular disease. We aimed to determine whether human immunodeficiency virus (HIV) status was independently associated with larger pericardial adipose tissue volume and to explore possible HIV-specific risk factors.METHODS: Persons with HIV (PWH) were recruited from the Copenhagen Comorbidity in HIV Infection (COCOMO) Study and matched 1:1 on age and sex to uninfected controls. Pericardial adipose tissue volume was measured using cardiac computed tomography.RESULTS: A total of 587 PWH and 587 controls were included. Median age was 52 years, and 88% were male. Human immunodeficiency virus status was independently associated with 17 mL (95% confidence interval [CI], 10-23; P < .001) larger pericardial adipose tissue volume. Larger pericardial adipose tissue volume was associated with low CD4+ nadir and prior use of stavudine, didanosine, and indinavir. Among PWH without thymidine analogue or didanosine exposure, time since initiating combination antiretroviral treatment (per 5-year use) was associated with l6 mL (95% CI, -6 to -25; P = .002) lower pericardial adipose tissue volume.CONCLUSIONS: Human immunodeficiency virus status was independently associated with larger pericardial adipose tissue volume. Severe immunodeficiency, stavudine, didanosine, and indinavir were associated with larger pericardial adipose tissue volume. Persons with HIV with prior exposure to these drugs may constitute a distinct cardiovascular risk population.

KW - Adipose Tissue/drug effects

KW - Adult

KW - Anti-HIV Agents/adverse effects

KW - Cardiovascular Diseases/chemically induced

KW - Denmark

KW - Didanosine/adverse effects

KW - Female

KW - HIV Infections/drug therapy

KW - HIV Protease Inhibitors/therapeutic use

KW - Healthy Volunteers

KW - Humans

KW - Indinavir/adverse effects

KW - Male

KW - Middle Aged

KW - Pericardium/physiopathology

KW - Risk Factors

KW - Stavudine/adverse effects

KW - Viral Load

U2 - 10.1093/infdis/jiaa057

DO - 10.1093/infdis/jiaa057

M3 - Journal article

C2 - 32027374

VL - 222

SP - 54

EP - 61

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

SN - 0022-1899

IS - 1

ER -

ID: 259515094