TY - JOUR

T1 - Percutaneous coronary intervention in calcified stenoses

T2 - a protocol for a systematic review with meta-analysis, trial sequential analysis and network meta-analysis

AU - Kristensen, Andreas Torp

AU - Jakobsen, Janus C.

AU - Olsen, Niels Thue

N1 - Publisher Copyright: © 2022 BMJ Publishing Group. All rights reserved.

PY - 2022

Y1 - 2022

N2 - Introduction Severely calcified coronary stenoses are difficult to treat with percutaneous coronary interventions. The presence of severe calcifications complicates lesion preparation, advancement of stents and achievement of full stent expansion. Intervention in these lesions is associated with an increased risk of complications and procedural failure compared with treatment of less calcified lesions. Due to the high burden of comorbidity, patients with severely calcified lesions are often excluded from interventional trials, and there is little evidence on how to treat these patients. Methods and analysis We will conduct a systematic review of randomised trials enrolling patients with calcified coronary artery disease undergoing percutaneous coronary intervention. We will investigate any percutaneous treatment option including any lesion preparation, stenting or postdilatation technique. We will search The Cochrane Central Register of Controlled Trials, Medical Literature Analysis and Retrieval System Online, Latin American and Caribbean Health Sciences Literature, Science Citation Index Expanded, and Excerpta Medica database for studies from inception to 31 October 2022. The coprimary outcome is all-cause mortality and serious adverse events. If appropriate, we will conduct meta-analysis, trial sequential analysis and network meta-analysis. Ethics and dissemination No ethics approval is required for this study. The results will be published in a peer-reviewed journal in this field. PROSPERO registration number CRD42021226034.

AB - Introduction Severely calcified coronary stenoses are difficult to treat with percutaneous coronary interventions. The presence of severe calcifications complicates lesion preparation, advancement of stents and achievement of full stent expansion. Intervention in these lesions is associated with an increased risk of complications and procedural failure compared with treatment of less calcified lesions. Due to the high burden of comorbidity, patients with severely calcified lesions are often excluded from interventional trials, and there is little evidence on how to treat these patients. Methods and analysis We will conduct a systematic review of randomised trials enrolling patients with calcified coronary artery disease undergoing percutaneous coronary intervention. We will investigate any percutaneous treatment option including any lesion preparation, stenting or postdilatation technique. We will search The Cochrane Central Register of Controlled Trials, Medical Literature Analysis and Retrieval System Online, Latin American and Caribbean Health Sciences Literature, Science Citation Index Expanded, and Excerpta Medica database for studies from inception to 31 October 2022. The coprimary outcome is all-cause mortality and serious adverse events. If appropriate, we will conduct meta-analysis, trial sequential analysis and network meta-analysis. Ethics and dissemination No ethics approval is required for this study. The results will be published in a peer-reviewed journal in this field. PROSPERO registration number CRD42021226034.

KW - Coronary intervention

KW - Ischaemic heart disease

KW - Myocardial infarction

U2 - 10.1136/bmjopen-2022-063884

DO - 10.1136/bmjopen-2022-063884

M3 - Review

C2 - 36691161

AN - SCOPUS:85138513736

VL - 12

JO - BMJ Open

JF - BMJ Open

SN - 2044-6055

IS - 9

M1 - e063884

ER -