Percutaneous atrial appendage occlusion for stroke prevention in patients with atrial fibrillation: a systematic review
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Percutaneous atrial appendage occlusion for stroke prevention in patients with atrial fibrillation : a systematic review. / Munkholm-Larsen, Stine; Cao, Christopher; Yan, Tristan D; Pehrson, Steen; Dixen, Ulrik.
I: Heart, Bind 98, Nr. 12, 2012, s. 900-7.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Percutaneous atrial appendage occlusion for stroke prevention in patients with atrial fibrillation
T2 - a systematic review
AU - Munkholm-Larsen, Stine
AU - Cao, Christopher
AU - Yan, Tristan D
AU - Pehrson, Steen
AU - Dixen, Ulrik
PY - 2012
Y1 - 2012
N2 - This review aims to evaluate systematically the safety and efficacy of percutaneous left atrial appendage occlusion (PLAAO) in stroke prevention for patients with atrial fibrillation (AF). A systematic review of peer-reviewed journals on PLAAO before June 2011 was performed on three electronic databases. Fourteen studies were identified for evaluation. Overall, implantation was successful in 93% of all cases. Periprocedural mortality and stroke rates were 1.1% and 0.6%, respectively. The incidences of pericardial effusion/cardiac tamponade and device embolisation were 4% and 0.7%, respectively. At the time of the latest follow-up (up to 40 months), the overall incidence of stroke among all studies was 1.4% per annum. Existing evidence suggests that PLAAO is a relatively safe treatment for patients with AF. However, there is a need for further evaluation of its efficacy in the form of large and well-designed randomised controlled trials.
AB - This review aims to evaluate systematically the safety and efficacy of percutaneous left atrial appendage occlusion (PLAAO) in stroke prevention for patients with atrial fibrillation (AF). A systematic review of peer-reviewed journals on PLAAO before June 2011 was performed on three electronic databases. Fourteen studies were identified for evaluation. Overall, implantation was successful in 93% of all cases. Periprocedural mortality and stroke rates were 1.1% and 0.6%, respectively. The incidences of pericardial effusion/cardiac tamponade and device embolisation were 4% and 0.7%, respectively. At the time of the latest follow-up (up to 40 months), the overall incidence of stroke among all studies was 1.4% per annum. Existing evidence suggests that PLAAO is a relatively safe treatment for patients with AF. However, there is a need for further evaluation of its efficacy in the form of large and well-designed randomised controlled trials.
U2 - 10.1136/heartjnl-2011-301256
DO - 10.1136/heartjnl-2011-301256
M3 - Journal article
C2 - 22511532
VL - 98
SP - 900
EP - 907
JO - Heart
JF - Heart
SN - 1355-6037
IS - 12
ER -
ID: 48439524