Pentraxins in Complement Activation and Regulation
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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Pentraxins in Complement Activation and Regulation. / Ma, Ying Jie; Garred, Peter.
I: Frontiers in Immunology, Bind 9, 3046, 2018.Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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TY - JOUR
T1 - Pentraxins in Complement Activation and Regulation
AU - Ma, Ying Jie
AU - Garred, Peter
PY - 2018
Y1 - 2018
N2 - The complement is the first line of immune defense system involved in elimination of invading pathogens and dying host cells. Its activation is mainly triggered by immune complexes or pattern recognition molecules (PRMs) upon recognition against non-self or altered self-cells, such as C1q, collectins, ficolins, and properdin. Recent findings have interestingly shown that the pentraxins (C-reactive protein, CRP; serum-amyloid P component, SAP; long pentraxin 3, PTX3) are involved in complement activation and amplification via communication with complement initiation PRMs, but also complement regulation via recruitment of complement regulators, for instance C4b binding protein (C4BP) and factor H (fH). This review addresses the potential roles of the pentraxins in the complement system during infection and inflammation, and emphasizes the underlining implications of the pentraxins in the context of complement activation and regulation both under physiological and pathological conditions.
AB - The complement is the first line of immune defense system involved in elimination of invading pathogens and dying host cells. Its activation is mainly triggered by immune complexes or pattern recognition molecules (PRMs) upon recognition against non-self or altered self-cells, such as C1q, collectins, ficolins, and properdin. Recent findings have interestingly shown that the pentraxins (C-reactive protein, CRP; serum-amyloid P component, SAP; long pentraxin 3, PTX3) are involved in complement activation and amplification via communication with complement initiation PRMs, but also complement regulation via recruitment of complement regulators, for instance C4b binding protein (C4BP) and factor H (fH). This review addresses the potential roles of the pentraxins in the complement system during infection and inflammation, and emphasizes the underlining implications of the pentraxins in the context of complement activation and regulation both under physiological and pathological conditions.
KW - collectin
KW - complement activation
KW - complement regulation
KW - CRP
KW - pentraxins
KW - PTX3
KW - SAP
KW - the ficolins
U2 - 10.3389/fimmu.2018.03046
DO - 10.3389/fimmu.2018.03046
M3 - Review
C2 - 30619374
VL - 9
JO - Frontiers in Immunology
JF - Frontiers in Immunology
SN - 1664-3224
M1 - 3046
ER -
ID: 218650663